The difluoromethyl functionality has proven useful in drug discovery, as it can modulate the
properties of bioactive molecules. For PET imaging, this structural motif has been largely …

Positron emission tomography (PET) is a preclinical and clinical imaging technique
extensively used to study and visualize biological and physiological processes in vivo …

Despite a growing interest in CHF2 in medicinal chemistry, there is a lack of efficient
methods for the insertion of CHF18F into druglike compounds. Herein described is a …

Molecules labelled with the unnatural isotope fluorine-18 are used for positron emission
tomography. Currently, this molecular imaging technology is not exploited at its full potential …

Fluoroform is an interesting motif for the isotopologue labelling of biologically active
compounds with fluorine‐18 for PET imaging. However, so far the building block [18F] …

Positron emission tomography (PET) is a preclinical and clinical imaging technique that is
extensively used in biomedical research and disease diagnosis to study and visualize …

Aliphatic fluorine‐18 radiolabeling is the most commonly used method to synthesize tracers
for PET‐imaging. With an increasing demand for 18F‐radiotracers for clinical applications …

Positron emission tomography has emerged as the leading method for medical imaging with
fluorine‐18 as the most widely used radioactive isotope. Here we report a semi‐automated …

INTRODUCTION: The translation of 11C-labeled compounds into their respective 18F-
labeled derivatives is an important tool in the rapid development of positron emission …

The positron emission tomography (PET) molecular imaging technology has gained
universal value as a critical tool for assessing biological and biochemical processes in living …