The relationship between the age-associated decline in mitochondrial function and its effect
on skeletal muscle physiology and function remain unclear. In the current study, we …

Aging is associated with mitochondrial dysfunction, which leads to a decline in cellular
function and the development of age-related diseases. Reduced skeletal muscle mass with …

Background The concept of mitochondrial dysfunction in ageing muscle is highly
controversial. In addition, emerging evidence suggests that reduced muscle oxidative …

Mitochondria are the hub for energy production within living cells. They can undergo
morphological changes in response to nutrient availability and cellular stress. Here, we …

Skeletal muscle health is dependent on the optimal function of its mitochondria. With
advancing age, decrements in numerous mitochondrial variables are evident in muscle. Part …

Mitochondrial function in human skeletal muscle declines with age. Most evidence for this
decline comes from studies that assessed mitochondrial function indirectly, and the impact of …

Aging is characterized by a progressive loss of muscle mass and muscle strength. Declines
in skeletal muscle mitochondria are thought to play a primary role in this process …

It has been established that the impairment of mitochondrial function is associated with
various disorders, such as type 2 diabetes and Alzheimer's disease. In addition …

Perturbations in mitochondrial health may foster age-related losses of aerobic capacity
(VO2peak) and skeletal muscle size. However, limited data exist regarding mitochondrial …

Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging
process. A growing body of research in the areas of bioenergetics and protein turnover has …