[HTML][HTML] HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adults
Abstract Background Type 2 Diabetes (T2D) is influenced by genetic, environmental, and
ageing factors. Ageing pathways exacerbate metabolic diseases. This study aimed to …
ageing factors. Ageing pathways exacerbate metabolic diseases. This study aimed to …
Stratification of type 2 diabetes by age of diagnosis in the UK Biobank reveals subgroup-specific genetic associations and causal risk profiles
The pathogenesis of type 2 diabetes (T2D) might change with increasing age. Here, we
used a stratification based on age of diagnosis to gain insight into the genetics and causal …
used a stratification based on age of diagnosis to gain insight into the genetics and causal …
Genetic predisposition to dyslipidemia and type 2 diabetes risk in two prospective cohorts
Dyslipidemia has been associated with type 2 diabetes, but it remains unclear whether
dyslipidemia plays a causal role in type 2 diabetes. We aimed to examine the association …
dyslipidemia plays a causal role in type 2 diabetes. We aimed to examine the association …
Association between lipids and apolipoproteins on type 2 diabetes risk; moderating effects of gender and polymorphisms; the ATTICA study
Background and aims Type 2 diabetes mellitus (T2DM) is a condition defined by
hyperglycaemia, but also often presents with dyslipidaemia and suppressed HDL …
hyperglycaemia, but also often presents with dyslipidaemia and suppressed HDL …
Phenotypic and genetic characterization of lower LDL cholesterol and increased type 2 diabetes risk in the UK Biobank
YC Klimentidis, A Arora, M Newell, J Zhou… - Diabetes, 2020 - Am Diabetes Assoc
Although hyperlipidemia is traditionally considered a risk factor for type 2 diabetes (T2D),
evidence has emerged from statin trials and candidate gene investigations suggesting that …
evidence has emerged from statin trials and candidate gene investigations suggesting that …
[HTML][HTML] LDL-C plays a causal role on T2DM: a Mendelian randomization analysis
W Pan, W Sun, S Yang, H Zhuang, H Jiang, H Ju… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Diabetic dyslipidemia is a common condition in patients with Type 2 diabetes mellitus
(T2DM). However, with the increasing application of statins which mainly decrease low …
(T2DM). However, with the increasing application of statins which mainly decrease low …
Association between dyslipidemia and risk of type 2 diabetes mellitus in middle-aged and older Chinese adults: a secondary analysis of a nationwide cohort
J Peng, F Zhao, X Yang, X Pan, J Xin, M Wu… - BMJ open, 2021 - bmjopen.bmj.com
Aims To evaluate the type 2 diabetes mellitus (T2DM) risk of individuals with different types
of dyslipidaemia and compare the predictive value of distinct lipid parameters in predicting …
of dyslipidaemia and compare the predictive value of distinct lipid parameters in predicting …
Clinical and genetic determinants of progression of type 2 diabetes: a DIRECT study
K Zhou, LA Donnelly, AD Morris, PW Franks… - Diabetes …, 2014 - Am Diabetes Assoc
OBJECTIVE To identify the clinical and genetic factors that explain why the rate of diabetes
progression is highly variable between idividuals following diagnosis of type 2 diabetes …
progression is highly variable between idividuals following diagnosis of type 2 diabetes …
Association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of type 2 diabetes mellitus among Chinese elderly: the Beijing …
D Zheng, H Li, F Ai, F Sun, M Singh, X Cao… - BMJ Open Diabetes …, 2020 - drc.bmj.com
Objective Time-dependent covariates are generally available as longitudinal data were
collected periodically in the cohort study. To examine whether time-dependent triglyceride to …
collected periodically in the cohort study. To examine whether time-dependent triglyceride to …
Comprehensive analysis of established Dyslipidemia-Associated loci in the diabetes prevention program
TV Varga, AH Winters, KA Jablonski… - Circulation …, 2016 - Am Heart Assoc
Background—We assessed whether 234 established dyslipidemia-associated loci modify
the effects of metformin treatment and lifestyle intervention (versus placebo control) on lipid …
the effects of metformin treatment and lifestyle intervention (versus placebo control) on lipid …