[HTML][HTML] HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adults

SO Sullivan, C Al Hageh, A Henschel, S Chacar… - Lipids in Health and …, 2024 - Springer
Abstract Background Type 2 Diabetes (T2D) is influenced by genetic, environmental, and
ageing factors. Ageing pathways exacerbate metabolic diseases. This study aimed to …

Stratification of type 2 diabetes by age of diagnosis in the UK Biobank reveals subgroup-specific genetic associations and causal risk profiles

R Noordam, K Läll, RAJ Smit, T Laisk, A Metspalu… - Diabetes, 2021 - Am Diabetes Assoc
The pathogenesis of type 2 diabetes (T2D) might change with increasing age. Here, we
used a stratification based on age of diagnosis to gain insight into the genetics and causal …

Genetic predisposition to dyslipidemia and type 2 diabetes risk in two prospective cohorts

Q Qi, L Liang, A Doria, FB Hu, L Qi - Diabetes, 2012 - Am Diabetes Assoc
Dyslipidemia has been associated with type 2 diabetes, but it remains unclear whether
dyslipidemia plays a causal role in type 2 diabetes. We aimed to examine the association …

Association between lipids and apolipoproteins on type 2 diabetes risk; moderating effects of gender and polymorphisms; the ATTICA study

DD Mellor, EN Georgousopoulou, NM D'cunha… - Nutrition, Metabolism …, 2020 - Elsevier
Background and aims Type 2 diabetes mellitus (T2DM) is a condition defined by
hyperglycaemia, but also often presents with dyslipidaemia and suppressed HDL …

Phenotypic and genetic characterization of lower LDL cholesterol and increased type 2 diabetes risk in the UK Biobank

YC Klimentidis, A Arora, M Newell, J Zhou… - Diabetes, 2020 - Am Diabetes Assoc
Although hyperlipidemia is traditionally considered a risk factor for type 2 diabetes (T2D),
evidence has emerged from statin trials and candidate gene investigations suggesting that …

[HTML][HTML] LDL-C plays a causal role on T2DM: a Mendelian randomization analysis

W Pan, W Sun, S Yang, H Zhuang, H Jiang, H Ju… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Diabetic dyslipidemia is a common condition in patients with Type 2 diabetes mellitus
(T2DM). However, with the increasing application of statins which mainly decrease low …

Association between dyslipidemia and risk of type 2 diabetes mellitus in middle-aged and older Chinese adults: a secondary analysis of a nationwide cohort

J Peng, F Zhao, X Yang, X Pan, J Xin, M Wu… - BMJ open, 2021 - bmjopen.bmj.com
Aims To evaluate the type 2 diabetes mellitus (T2DM) risk of individuals with different types
of dyslipidaemia and compare the predictive value of distinct lipid parameters in predicting …

Clinical and genetic determinants of progression of type 2 diabetes: a DIRECT study

K Zhou, LA Donnelly, AD Morris, PW Franks… - Diabetes …, 2014 - Am Diabetes Assoc
OBJECTIVE To identify the clinical and genetic factors that explain why the rate of diabetes
progression is highly variable between idividuals following diagnosis of type 2 diabetes …

Association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of type 2 diabetes mellitus among Chinese elderly: the Beijing …

D Zheng, H Li, F Ai, F Sun, M Singh, X Cao… - BMJ Open Diabetes …, 2020 - drc.bmj.com
Objective Time-dependent covariates are generally available as longitudinal data were
collected periodically in the cohort study. To examine whether time-dependent triglyceride to …

Comprehensive analysis of established Dyslipidemia-Associated loci in the diabetes prevention program

TV Varga, AH Winters, KA Jablonski… - Circulation …, 2016 - Am Heart Assoc
Background—We assessed whether 234 established dyslipidemia-associated loci modify
the effects of metformin treatment and lifestyle intervention (versus placebo control) on lipid …