We have reviewed the published data regarding radiotherapy (RT)-induced brain injury.
Radiation necrosis appears a median of 1–2 years after RT; however, cognitive decline …

Radiation is an invaluable therapeutic tool in the treatment of cancer, with well-established
palliative and curative efficacy. As patient survival has improved, attention has focused on …

Publications relating brainstem radiation toxicity to quantitative dose and dose–volume
measures derived from three-dimensional treatment planning were reviewed. Despite the …

Purpose: To investigate radiation necrosis in patients treated for glioma in terms of
incidence, outcomes, predictive and prognostic factors. Methods and Materials: Records …

We critically examined the damaging affects of therapeutic irradiation by comparing results
from cross-disciplinary studies of early-and late-delayed radiotherapy effects. Focus is …

Radiation therapy is a mainstay of cancer treatment, particularly for patients with nervous
system tumors. Like most cancer treatments, radiation is nonspecifically cytotoxic. As a …

Brain injury by radiation therapy (RT) has traditionally been classified according to its time of
onset into acute, early delayed, and late forms. The acute reaction to fractionated RT usually …

Purpose and Objectives Neurologic deficits after brain radiation therapy (RT) typically
involve decline in higher-order cognitive functions such as attention and memory rather than …

The authors irradiated 152 patients with primary brain and pituitary tumors from 1974 to
1976. Seven of 139 patients (5%) who received 4500 rad or greater using 180 to 200 rad …

Forty-one patients treated for primary malignancies of the brain at the University of
Rochester Cancer Center since 1970 were assessed for adverse effects of irradiation …