Granulocytes provide a fast innate response to pathogens and allergens. In allergy and anti‐
helminth immunity, epithelial cells of damaged barriers release alarmins like IL‐25, IL‐33 …

Allergic diseases comprise a series of distinct clinical syndromes like atopic dermatitis,
allergic asthma, allergic rhinitis, food allergy, and systemic anaphylaxis that have a common …

Mast cells are myeloid hematopoietic cells located primarily at body interfaces, such as the
skin and gut. 1 Mast cells are known to mediate IgE-associated allergic responses …

Persistent irritants that are resistant to innate and cognate immunity induce granulomas.
These macrophage-dominated lesions that partially isolate the healthy tissue from the irritant …

Mast cell activation releases the mediators associated with type I allergy. As such, the study
of mast cell activation is critical for understanding the allergic reaction, and for developing …

Highlights•Mast cells and basophils have similar morphological characteristics and express
the high-affinity FceRI on their cell surface.•Genetically engineered deletion mice …

The allergic inflammatory response is composed of two main phases—the early and the late.
The early phase initiates when an allergen activates the tissue resident mast cell, triggering …

Neutrophils are cells of the innate immune system that are extremely abundant in vivo and
respond quickly to infection, injury, and inflammation. Their constant circulation throughout …

It has become apparent that the resolution of inflammation depends on the removal of
unwanted inflammatory cells, a process governed by physiological apoptosis and non …

IgE, mast cells, basophils, and eosinophils are essential components of allergic
inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcεRI …