Fungal conditions affect a multitude of people worldwide, leading to increased
hospitalization and mortality rates, and the need for novel antifungals is emerging with the …

Fungal infections have greatly contributed to infectious-related deaths in the past century.
This issue has become worse with the advent of immunity-impairing conditions such as HIV …

With the increasing risk of invasive and life threating fungal infections, there is now a great
concern regarding the lower discovery rate of antifungal drugs in comparison to …

Triazoles have demonstrated significant efficacy in the treatment of fungal infections.
However, increasing drug resistance is a growing concern that negatively impacts their …

Today's research is focused on developing new safe drugs of clinical importance. Nitrogen-
containing heterocycles are abundant in the common of therapeutic scaffolds. Triazoles are …

Due to their eukaryotic heritage, the differences between a fungal pathogen's molecular
makeup and its human host are small. Therefore, the discovery and subsequent …

An increasing clinical burden of fungal disease is associated with chronic (eg chronic
pulmonary aspergillosis), systemic (eg candidemia and cryptococcal meningoencephalitis) …

Previous work led to the rational design, synthesis and testing of novel antifungal triazole
analogues bearing alkynyl-methoxyl side chains. Tests of in vitro antifungal activity showed …

Fungal infections are a universal problem and are routinely associated with high morbidity
and mortality rates in immunocompromised patients. Existing therapies comprise five …

Introduction: Superficial infections involving the skin and mucosa are the most common
fungal disease in humans. Fungi can also produce invasive infections (IFI), which are …