Imaging live cells grown on a three dimensional collagen matrix using Raman microspectroscopy

F Bonnier, P Knief, B Lim, AD Meade, J Dorney… - Analyst, 2010 - pubs.rsc.org
Three dimensional collagen gels have been used as matrices for the imaging of live cells by
Raman spectroscopy. The study is conducted on a human lung adenocarcinoma (A549) and …

Three dimensional collagen gels as a cell culture matrix for the study of live cells by Raman spectroscopy

F Bonnier, AD Meade, S Merzha, P Knief… - Analyst, 2010 - pubs.rsc.org
Three dimensional collagen gels are evaluated as matrices for the study of live cells by
Raman spectroscopy. The study is conducted on a human lung adenocarcinoma (A549) and …

Raman spectroscopy detects biochemical changes due to different cell culture environments in live cells in vitro

M Gargotti, E Efeoglu, HJ Byrne, A Casey - Analytical and bioanalytical …, 2018 - Springer
The in vitro cell culture environment can impact on cell biochemistry and cell cycle. The
manifestation of such substrate-induced changes in cell cycle in the Raman …

3D confocal Raman imaging of endothelial cells and vascular wall: perspectives in analytical spectroscopy of biomedical research

K Majzner, A Kaczor, N Kachamakova-Trojanowska… - Analyst, 2013 - pubs.rsc.org
Raman imaging was used to illustrate heterogeneity of a single endothelial cell and the
vascular wall sample. The spectral analysis allowed for exploring the complexity of the …

Raman microspectroscopy: a noninvasive analysis tool for monitoring of collagen-containing extracellular matrix formation in a medium-throughput culture system

A Kunstar, C Otto, M Karperien… - … Engineering Part C …, 2011 - liebertpub.com
The three-dimensional environment is known to play an important role in promoting cell–
matrix interactions. We have investigated the possibility of using Raman microspectroscopy …

Chemical imaging of articular cartilage sections with Raman mapping, employing uni-and multi-variate methods for data analysis

A Bonifacio, C Beleites, F Vittur, E Marsich, S Semeraro… - Analyst, 2010 - pubs.rsc.org
Raman mapping in combination with uni-and multi-variate methods of data analysis is
applied to articular cartilage samples. Main differences in biochemical composition and …

In vitro analysis of immersed human tissues by Raman microspectroscopy

F Bonnier, A Mehmood, P Knief… - Journal of Raman …, 2011 - Wiley Online Library
Raman microspectroscopy is a powerful tool for the analysis of tissue sections, providing a
molecular map of the investigated samples. Nevertheless, data pre‐processing and …

Confocal three‐dimensional scanning laser Raman–SERS–fluorescence microprobe. Spectral imaging and high‐resolution applications

S Sharonov, I Nabiev, I Chourpa… - Journal of Raman …, 1994 - Wiley Online Library
A multi‐purpose instrument which allows the recording of confocal micro‐Raman, micro‐
SERS and micro‐fluorescence spectral images of sample areas from 5× 5 to l50× l50 μm …

Raman spectroscopy in biomedicine–non‐invasive in vitro analysis of cells and extracellular matrix components in tissues

E Brauchle, K Schenke‐Layland - Biotechnology journal, 2013 - Wiley Online Library
Raman spectroscopy is an established laser‐based technology for the quality assurance of
pharmaceutical products. Over the past few years, Raman spectroscopy has become a …

Multivariate analysis of Raman spectra for in vitro non-invasive studies of living cells

I Notingher, G Jell, PL Notingher, I Bisson… - Journal of molecular …, 2005 - Elsevier
Understanding the biochemical and biophysical properties of live cells is fundamental for
unravelling the secrets of many diseases and developing new therapies. Raman micro …