Myelomeningocele (MMC) affects one in 1000 newborns annually worldwide and each
surviving child faces tremendous lifetime medical and caregiving burdens. Both genetic and …

Background Myelomeningocele (MMC) is the most severe and frequent type of spina bifida.
Its etiology remains poorly understood. The Hedgehog (Hh), Wnt, and planar cell polarity …

Genes in the noncanonical WNT signaling pathway controlling planar cell polarity have
been linked to the neural tube defect myelomeningocele. We hypothesized that some genes …

BACKGROUND A common and severe neural tube defect (NTD) phenotype,
myelomeningocele (MM), results from the defective closure of the caudal end of the neural …

Background Neural tube defects (NTDs) are very common and severe birth defects that are
caused by failure of neural tube closure and that have a complex aetiology. Anencephaly …

Abstract Background Neural tube defects (NTDs) are the second most common complex
birth defect, yet, our understanding of the genetic contribution to their development remains …

Neural tube defects (NTDs) are common birth defects of complex etiology. Family and
population-based studies have confirmed a genetic component to NTDs. However, despite …

Background Cell-free RNA in amniotic fluid supernatant reflects developmental changes in
gene expression in the living fetus, which includes genes that are specific to the central …

Objective Excessive oxidative stress has been demonstrated as a mechanism for neural
tube defects (NTDs). The current exploratory study sought to examine sequence variations …

Spina bifida is a birth defect in which the vertebral column is open, often with spinal cord
involvement. The most clinically significant subtype is myelomeningocele (open spina …