Genome-wide analysis of somatic noncoding mutation patterns in cancer
We established a genome-wide compendium of somatic mutation events in 3949 whole
cancer genomes representing 19 tumor types. Protein-coding events captured well …
cancer genomes representing 19 tumor types. Protein-coding events captured well …
Somatic mutation in cancer and normal cells
I Martincorena, PJ Campbell - Science, 2015 - science.org
Spontaneously occurring mutations accumulate in somatic cells throughout a person's
lifetime. The majority of these mutations do not have a noticeable effect, but some can alter …
lifetime. The majority of these mutations do not have a noticeable effect, but some can alter …
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
INTRODUCTION Cancer genome studies have contributed to the analysis and discovery of
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
Mutational processes underlie cancer initiation and progression. Signatures of these
processes in cancer genomes may explain cancer etiology and could hold diagnostic and …
processes in cancer genomes may explain cancer etiology and could hold diagnostic and …
The repertoire of mutational signatures in human cancer
Somatic mutations in cancer genomes are caused by multiple mutational processes, each of
which generates a characteristic mutational signature. Here, as part of the Pan-Cancer …
which generates a characteristic mutational signature. Here, as part of the Pan-Cancer …
The consensus coding sequences of human breast and colorectal cancers
The elucidation of the human genome sequence has made it possible to identify genetic
alterations in cancers in unprecedented detail. To begin a systematic analysis of such …
alterations in cancers in unprecedented detail. To begin a systematic analysis of such …
Cancer genome landscapes
Over the past decade, comprehensive sequencing efforts have revealed the genomic
landscapes of common forms of human cancer. For most cancer types, this landscape …
landscapes of common forms of human cancer. For most cancer types, this landscape …
High-resolution interrogation of functional elements in the noncoding genome
The noncoding genome affects gene regulation and disease, yet we lack tools for rapid
identification and manipulation of noncoding elements. We developed a CRISPR screen …
identification and manipulation of noncoding elements. We developed a CRISPR screen …
First pass at cancer genome reveals complex landscape
J Kaiser - 2006 - science.org
Scientists have long known that the sparks that kindle cancer are mutations in a cell's genes.
But most cancer-causing mutations have been discovered by looking in obvious places …
But most cancer-causing mutations have been discovered by looking in obvious places …
The genomic landscapes of human breast and colorectal cancers
Human cancer is caused by the accumulation of mutations in oncogenes and tumor
suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we …
suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we …