Aged hematopoietic stem cells (HSCs) are impaired in supporting hematopoiesis. The
molecular and cellular mechanisms of stem cell aging are not well defined. HSCs interact …

Intravital microscopy of the calvarium is the only noninvasive method for high-resolution
imaging of the bone marrow (BM) and hematopoietic stem cell (HSC) niches. However, it is …

Haematopoietic stem cell (HSC) niches, although proposed decades ago, have only
recently been identified as separate osteoblastic and vascular microenvironments,,,,. Their …

Prior research establishing that bone interacts in coordination with the bone marrow
microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on …

Adult mammalian hematopoietic stem cells (HSCs) reside in the bone marrow (BM) but can
be mobilized into blood for use in transplantation. HSCs interact with BM niche cells that …

Intravital two-photon microscopy enables deep-tissue imaging at high temporospatial
resolution in live animals. However, the endosteal bone compartment and underlying bone …

The bone marrow is a central organ of the immune system, which hosts complex interactions
of bone and immune compartments critical for hematopoiesis, immunological memory, and …

Identifying and understanding the roles of all cells comprising the HSC niche coupled with
the development of better 3D imaging and 3D in-vitro mimicking of the HSC niche will …

Hematopoietic ageing involves declining erythropoiesis and lymphopoiesis, leading to
frequent anaemia and decreased adaptive immunity. How intrinsic changes to the …

The bone marrow (BM) microenvironment contains many types of cells and molecules with
roles in hematopoiesis, osteogenesis, angiogenesis and metabolism. The spatial …