Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones
A Köhler, V Schmithorst, MD Filippi… - Blood, The Journal …, 2009 - ashpublications.org
Aged hematopoietic stem cells (HSCs) are impaired in supporting hematopoiesis. The
molecular and cellular mechanisms of stem cell aging are not well defined. HSCs interact …
molecular and cellular mechanisms of stem cell aging are not well defined. HSCs interact …
Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: functional implications on hematopoietic stem cells
F Lassailly, K Foster, L Lopez-Onieva… - Blood, The Journal …, 2013 - ashpublications.org
Intravital microscopy of the calvarium is the only noninvasive method for high-resolution
imaging of the bone marrow (BM) and hematopoietic stem cell (HSC) niches. However, it is …
imaging of the bone marrow (BM) and hematopoietic stem cell (HSC) niches. However, it is …
Detection of functional haematopoietic stem cell niche using real-time imaging
Y Xie, T Yin, W Wiegraebe, XC He, D Miller, D Stark… - Nature, 2009 - nature.com
Haematopoietic stem cell (HSC) niches, although proposed decades ago, have only
recently been identified as separate osteoblastic and vascular microenvironments,,,,. Their …
recently been identified as separate osteoblastic and vascular microenvironments,,,,. Their …
The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies
H Zhang, JL Liesveld, LM Calvi, BC Lipe, L Xing… - Bone Research, 2023 - nature.com
Prior research establishing that bone interacts in coordination with the bone marrow
microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on …
microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on …
Intravital imaging reveals motility of adult hematopoietic stem cells in the bone marrow niche
S Upadhaya, O Krichevsky, I Akhmetzyanova… - Cell Stem Cell, 2020 - cell.com
Adult mammalian hematopoietic stem cells (HSCs) reside in the bone marrow (BM) but can
be mobilized into blood for use in transplantation. HSCs interact with BM niche cells that …
be mobilized into blood for use in transplantation. HSCs interact with BM niche cells that …
Minimally invasive longitudinal intravital imaging of cellular dynamics in intact long bone
ND Bhattacharyya, W Kyaw, MM McDonald… - Nature …, 2023 - nature.com
Intravital two-photon microscopy enables deep-tissue imaging at high temporospatial
resolution in live animals. However, the endosteal bone compartment and underlying bone …
resolution in live animals. However, the endosteal bone compartment and underlying bone …
Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature
D Reismann, J Stefanowski, R Günther… - Nature …, 2017 - nature.com
The bone marrow is a central organ of the immune system, which hosts complex interactions
of bone and immune compartments critical for hematopoiesis, immunological memory, and …
of bone and immune compartments critical for hematopoiesis, immunological memory, and …
Bone, microenvironment and hematopoiesis
Y Shen, SK Nilsson - Current opinion in hematology, 2012 - journals.lww.com
Identifying and understanding the roles of all cells comprising the HSC niche coupled with
the development of better 3D imaging and 3D in-vitro mimicking of the HSC niche will …
the development of better 3D imaging and 3D in-vitro mimicking of the HSC niche will …
Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing
Hematopoietic ageing involves declining erythropoiesis and lymphopoiesis, leading to
frequent anaemia and decreased adaptive immunity. How intrinsic changes to the …
frequent anaemia and decreased adaptive immunity. How intrinsic changes to the …
Three-dimensional map of nonhematopoietic bone and bone-marrow cells and molecules
The bone marrow (BM) microenvironment contains many types of cells and molecules with
roles in hematopoiesis, osteogenesis, angiogenesis and metabolism. The spatial …
roles in hematopoiesis, osteogenesis, angiogenesis and metabolism. The spatial …