Bacteria defend against phage infection via a variety of antiphage defense systems. Many
defense systems were recently shown to deplete cellular nicotinamide adenine dinucleotide …

Depletion of nicotinamide adenine dinucleotide (NAD+), an important regulator of cellular
energy metabolism, is a common strategy in immune-mediated cell death (ICD) in both …

The astounding number of anti-phage defenses encoded by bacteria is countered by an
elaborate set of phage counter-defenses, though their evolutionary origins are often …

Abstract The Silent Information Regulator 2 (SIR2) protein is widely implicated in antiviral
response by depleting the cellular metabolite NAD+. The defense-associated sirtuin 2 …

Abstract Defense-associated sirtuin 2 (DSR2) systems are widely distributed across
prokaryotic genomes, providing robust protection against phage infection. DSR2 recognizes …

DSR2 belongs to the family of defense-associated sirtuins (DSRs) which protect bacteria
from phage infection by hydrolyzing NAD+. Phage propagation is effectively inhibited …

Results In this study, we aimed to explore whether short pAgos can act as prokaryotic
defence systems against viruses or plasmids. To this end, we selected two short pAgos …

Abstract Silent information regulator 2 (Sir2) proteins typically catalyze NAD+-dependent
protein deacetylation. The recently identified bacterial Sir2 domain-containing protein …

Declines in cellular nicotinamide adenine dinucleotide (NAD) contribute to metabolic
dysfunction, increase susceptibility to disease, and occur as a result of pathogenic infection …

Nicotinamide adenine dinucleotide (NAD) serves as a cap-like structure on cellular RNAs
(NAD-RNAs) in all domains of life including the bacterium Escherichia coli. NAD also acts as …