The emergence of mitochondria as critical regulators of cardiac myocyte survival and death
has revolutionized the field of cardiac biology. Indeed, it is now well recognized that …

Mitochondria are important generators of energy, providing ATP through oxidative
phosphorylation. However, mitochondria also monitor complex information from the …

Mitochondria have long been recognized for their central role in energy transduction and
apoptosis. More recently, extensive work in multiple laboratories around the world has …

Since the discovery that mitochondrial membrane permeabilization represents a critical step
in the regulation of intrinsic apoptosis, mitochondria have been viewed as pluripotent …

As the heart is an energy-demanding organ, impaired cardiac energy metabolism and
mitochondrial function have been inexorably linked to cardiac dysfunction. There is a …

Mitochondria are primarily responsible for providing the contracting cardiac myocyte with a
continuous supply of ATP. However, mitochondria can rapidly change into death-promoting …

Mitochondria respond to signals from the cytoplasmic environment, including energy needs,
substrate and oxygen availability, ion fluxes, as well as kinase and proteolytic signals. They …

Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …

Over the past decade, mitochondria have emerged as critical integrators of energy
production, generation of reactive oxygen species (ROS), multiple cell death, and signaling …

Cardiovascular disease is a major leading cause of morbidity and mortality in the United
States and elsewhere. Alterations in mitochondrial function are increasingly being …