Mouse and human immune responses share neutralization epitopes of HAstV-VA1

I Ramírez-Bello, T López, R Espinosa, A Ghosh… - Journal of …, 2024 - journals.asm.org
Astroviruses are highly divergent and infect a wide variety of animal hosts. In 2009, a
genetically divergent human astrovirus (HAstV) strain VA1 was first identified in an outbreak …

Isolation of neutralizing monoclonal antibodies to human astrovirus and characterization of virus variants that escape neutralization

R Espinosa, T López, WA Bogdanoff… - Journal of …, 2019 - Am Soc Microbiol
Human astroviruses (HAstVs) cause severe diarrhea and represent an important health
problem in children under two years of age. Despite their medical importance, the study of …

Structural basis for escape of human astrovirus from antibody neutralization: broad implications for rational vaccine design

WA Bogdanoff, EI Perez, T López, CF Arias… - Journal of …, 2018 - Am Soc Microbiol
Human astroviruses are recognized as a leading cause of viral diarrhea worldwide in
children, immunocompromised patients, and the elderly. There are currently no vaccines …

Structure of a human astrovirus capsid-antibody complex and mechanistic insights into virus neutralization

WA Bogdanoff, J Campos, EI Perez, L Yin… - Journal of …, 2017 - Am Soc Microbiol
Human astroviruses (HAstVs) are a leading cause of viral diarrhea in young children, the
immunocompromised, and the elderly. There are no vaccines or antiviral therapies against …

Human astroviruses: a tale of two strains

V Hargest, AE Davis, S Tan, V Cortez, S Schultz-Cherry - Viruses, 2021 - mdpi.com
Since the 1970s, eight closely related serotypes of classical human astroviruses (HAstV)
have been associated with gastrointestinal illness worldwide. In the late 2000s, three …

Structure and antigenicity of the divergent human astrovirus VA1 capsid spike

A Ghosh, K Delgado-Cunningham, T López… - Plos …, 2024 - journals.plos.org
Human astrovirus (HAstV) is a known cause of viral gastroenteritis in children worldwide, but
HAstV can cause also severe and systemic infections in immunocompromised patients …

Human astrovirus capsid protein releases a membrane lytic peptide upon trypsin maturation

M Ykema, K Ye, M Xun, J Harper… - Journal of …, 2023 - Am Soc Microbiol
The human astrovirus (HAstV) is a non-enveloped, single-stranded RNA virus that is a
common cause of gastroenteritis. Most non-enveloped viruses use membrane disruption to …

Molecular evolutionary analysis of type-1 human astroviruses identifies putative sites under selection pressure on the capsid protein

S De Grazia, G Lanave, F Bonura, N Urone… - Infection, Genetics and …, 2018 - Elsevier
Human astroviruses (HAstV) are important enteric pathogens that can be classified into eight
sero/genotypes (HAstV-1 to-8). Although the various HAstV types show global spread, type …

Structural, mechanistic, and antigenic characterization of the human astrovirus capsid

RL York, PA Yousefi, W Bogdanoff, S Haile… - Journal of …, 2016 - Am Soc Microbiol
Human astroviruses (HAstVs) are nonenveloped, positive-sense, single-stranded RNA
viruses that are a leading cause of viral gastroenteritis. HAstV particles display T= 3 …

Biology and cellular tropism of a unique astrovirus strain: Murine astrovirus 2

SP Kelly, RJ Ricart Arbona, AO Michel… - Comparative …, 2021 - ingentaconnect.com
Murine astrovirus 2 (MuAstV2) is a novel murine astrovirus recently identified in laboratory
and wild mice. MuAstV2 readily transmits between immunocompetent mice yet fails to …