Preclinical models of epithelial ovarian cancer: practical considerations and challenges for a meaningful application

A Ciucci, M Buttarelli, A Fagotti, G Scambia… - Cellular and Molecular …, 2022 - Springer
Despite many improvements in ovarian cancer diagnosis and treatment, until now,
conventional chemotherapy and new biological drugs have not been shown to cure the …

[HTML][HTML] Ovarian cancer: pathology, biology, and disease models

DG Rosen, G Yang, G Liu, I Mercado-Uribe… - … in bioscience: a …, 2009 - ncbi.nlm.nih.gov
Epithelial ovarian cancer, which comprises several histologic types and grades, is the most
lethal cancer among women in the United States. In this review, we summarize recent …

Ovarian cancer

KR Cho, IM Shih - Annual review of pathology: mechanisms of …, 2009 - annualreviews.org
Ovarian carcinomas are a heterogeneous group of neoplasms and are traditionally
subclassified based on type and degree of differentiation. Although current clinical …

Investigating the suitability of in vitro cell lines as models for the major subtypes of epithelial ovarian cancer

A McCabe, O Zaheed, SS McDade… - Frontiers in Cell and …, 2023 - frontiersin.org
Epithelial ovarian cancer (EOC) is the most fatal gynaecological malignancy, accounting for
over 200,000 deaths worldwide per year. EOC is a highly heterogeneous disease, classified …

[HTML][HTML] The promise and challenge of ovarian cancer models

N Hasan, AW Ohman, DM Dinulescu - Translational cancer …, 2015 - ncbi.nlm.nih.gov
The complexity and heterogeneity of ovarian cancer cases are difficult to reproduce in in
vitro studies, which cannot adequately elucidate the molecular events involved in tumor …

Current status and evolution of preclinical drug development models of epithelial ovarian cancer

PA Konstantinopoulos, UA Matulonis - Frontiers in oncology, 2013 - frontiersin.org
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and the fifth most
common cause of female cancer death in the United States. Although important advances in …

Revisiting ovarian cancer preclinical models: implications for a better management of the disease

F Ricci, M Broggini, G Damia - Cancer treatment reviews, 2013 - Elsevier
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Despite progress
in identifying “hallmark” genetic alterations associated with the main subtypes of epithelial …

Molecular pathogenesis and therapeutic targets in epithelial ovarian cancer

JR Chien, G Aletti, DA Bell, GL Keeney… - Journal of cellular …, 2007 - Wiley Online Library
Ovarian cancer, the most aggressive gynecologic cancer, is the foremost cause of death
from gynecologic malignancies in the developed world. Two primary reasons explain its …

Ovarian cancer update: lessons from morphology, molecules, and mice

KR Cho - Archives of pathology & laboratory medicine, 2009 - meridian.allenpress.com
Ovarian carcinomas are a heterogeneous group of neoplasms. Pathologists currently
employ a morphology-based classification system to divide ovarian carcinomas into major …

Molecular characterization of epithelial ovarian cancer: implications for diagnosis and treatment

V Rojas, KM Hirshfield, S Ganesan… - International journal of …, 2016 - mdpi.com
Epithelial ovarian cancer is a highly heterogeneous disease characterized by multiple
histological subtypes. Molecular diversity has been shown to occur within specific …