Abnormally phosphorylated tau, an indicator of Alzheimer's disease, accumulates in the first
decades of life in the locus coeruleus (LC), the brain's main noradrenaline supply. However …

Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …

The locus coeruleus (LC) is the noradrenaline (norepinephrine, NE)-containing nucleus in
the brainstem and innervates into widespread brain regions. This LC-NE system plays a …

Neuropathological studies showed early locus coeruleus (LC) neuronal loss associated with
tauopathy in Alzheimer's Disease (AD). We used the LC signal intensity (LC‐I) on 3T MRI to …

Alzheimer's disease (AD) is the most common cause of cognitive impairment in older
patients, and its prevalence is expected to soar in coming decades. Neuropathologically, AD …

Animal and human imaging research reported that the presence of cortical Alzheimer's
Disease's (AD) neuropathology, beta-amyloid and neurofibrillary tau, is associated with …

Abstract See Grinberg and Heinsen (doi: 10.1093/brain/awx261) for a scientific commentary
on this article. Clinical evidence suggests that aberrant tau accumulation in the locus …

Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

Alzheimer's disease (AD) represents the most prevalent form of dementia in the elderly.
However, the pathological mechanisms underlying the development and progression of AD …

The locus coeruleus (LC), a tiny nucleus in the brainstem and the principal site of
noradrenaline synthesis, has a major role in regulating autonomic function, arousal …