Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second-deadliest
infectious disease worldwide. Emerging evidence shows that the elongation factor EF-Tu …

During protein synthesis, translation elongation factor Tu (Ef-Tu) is responsible for the
selection and binding of the cognate aminoacyl-tRNA to the acceptor site on the ribosome …

ABSTRACT trans-Translation is conserved throughout bacteria and is essential in many
species. High-throughput screening identified a tetrazole-based trans-translation inhibitor …

During protein biosynthesis, elongation factor Tu (EF-Tu) delivers aminoacyl-tRNA (aa-
tRNA) to the A-site of ribosomes. This factor is highly conserved throughout evolution …

Abstract Background Elongation factor Tu (EF-Tu) in its GTP conformation is a carrier of
aminoacylated tRNAs (aa-tRNAs) to the ribosomal A site during protein biosynthesis. The …

Translation elongation factor EF-Tu belongs to the superfamily of guanine-nucleotide
binding proteins, which play key cellular roles as regulatory switches. All G-proteins require …

Prokaryotic elongation factors EF-Tu form a family of homologous, three-domain molecular
switches catalyzing the binding of aminoacyl-tRNAs to ribosomes during the process of …

Elongation factor thermal unstable Tu (EF-Tu) is a G protein that catalyzes the binding of
aminoacyl-tRNA to the A-site of the ribosome inside living cells. Structural and biochemical …

According to the traditional view, GTPases act as molecular switches, which cycle between
distinct 'on'and 'off'conformations bound to GTP and GDP, respectively. Translation …

In order to study the structural and functional requirements of the essential translational
GTPase elongation factor (EF) Tu for efficient and accurate ribosome-dependent protein …