Developments in Exploring Fungal Secondary Metabolites as Antiviral Compounds and Advances in HIV-1 Inhibitor Screening Assays

B Nzimande, JP Makhwitine, NP Mkhwanazi, SI Ndlovu - Viruses, 2023 - mdpi.com
The emergence of drug-resistant Human Immunodeficiency Virus-1 strains against anti-HIV
therapies in the clinical pipeline, and the persistence of HIV in cellular reservoirs remains a …

[HTML][HTML] Inhibition of HIV-1 replication by secondary metabolites from endophytic fungi of desert plants

BP Wellensiek, R Ramakrishnan… - The open virology …, 2013 - ncbi.nlm.nih.gov
Most antiretroviral drugs currently in use to treat an HIV-1 infection are chemically
synthesized and lead to the development of viral resistance, as well as cause severe …

In-vitro Assays for Determining Anti-HIV Potential of Phytochemicals

P Fonteh, W Chingwaru, D Meyer… - … : An in-silico and in-vitro …, 2019 - Springer
Abstract The Human Immunodeficiency Virus (HIV) infection and the associated acquired
immune deficiency syndrome (AIDS) remain global challenges even after decades of …

Potential of small-molecule fungal metabolites in antiviral chemotherapy

BG Roy - Antiviral Chemistry and Chemotherapy, 2017 - journals.sagepub.com
Various viral diseases, such as acquired immunodeficiency syndrome, influenza, and
hepatitis, have emerged as leading causes of human death worldwide. Scientific endeavor …

Antiretroviral agents: looking for the best possible chemotherapeutic options to conquer HIV

T Farooq, A Hameed, K Rehman… - Critical Reviews™ in …, 2016 - dl.begellhouse.com
For the last thirty years, ongoing efforts have revolutionized the antiretroviral therapy, which
changed human immunodeficiency virus (HIV) infections from terrifying lethal diseases to …

Epigenetic Induction of Secondary Metabolites Production in Endophytic Fungi Penicillium chrysogenum and GC-MS Analysis of Crude Metabolites with Anti-HIV-1 …

JP Makhwitine, HM Kumalo, SI Ndlovu, NP Mkhwanazi - Microorganisms, 2023 - mdpi.com
The continuous burden of human immunodeficiency virus-1 in Sub-Saharan Africa, coupled
with the inability of antiretroviral agents to eradicate HIV-1 from viral reservoirs, the potential …

Endophytic fungi as a source of antiviral compounds–a review

ÍCS Lacerda, JC Polonio, HC Golias - Chemistry & Biodiversity, 2022 - Wiley Online Library
Endophytic fungi are a rich source of secondary metabolites. The interactions between
endophytes and their hosts lead to the production of several bioactive substances grouped …

Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs

J Popović-Djordjević, C Quispe, R Giordo… - European journal of …, 2022 - Elsevier
The human immunodeficiency virus (HIV) is responsible for acquired immune deficiency
syndrome (AIDS), one of the major pandemic diseases. Highly active antiretroviral therapy …

Medicinal plants used in the treatment of human immunodeficiency virus

B Salehi, NVA Kumar, B Şener, M Sharifi-Rad… - International journal of …, 2018 - mdpi.com
Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected
around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There …

Antiviral agents from fungi: diversity, mechanisms and potential applications

R Linnakoski, D Reshamwala, P Veteli… - Frontiers in …, 2018 - frontiersin.org
Viral infections are amongst the most common diseases affecting people worldwide. New
viruses emerge all the time and presently we have limited number of vaccines and only few …