Effect of oridonin on cytochrome P450 expression and activities in HepaRG cell

Y Zhang, X Zheng, Y Liu, L Fang, Z Pan, M Bao… - Pharmacology, 2018 - karger.com
Oridonin, the major terpene found in Rabdosia rubescens, is widely used as a dietary
supplement or therapeutic drug. However, the effects of oridonin on major CYP450s are still …

Dose-response of oridonin on hepatic cytochromes P450 mRNA expression and activities in mice

Y Zhang, M Bao, L Hu, Q Qu, H Zhou - Journal of ethnopharmacology, 2014 - Elsevier
Ethnopharmacological relevance Oridonin, the major terpene found in Rabdosia rubescens,
is widely used as a dietary supplement or therapeutic drug. The effects of oridonin on drug …

Effects of oridonin on hepatic cytochrome P450 expression and activities in PXR-humanized mice

Z Yi-Wen, B Mei-Hua, L Xiao-Ya, C Yu… - Biological and …, 2018 - jstage.jst.go.jp
Oridonin, the major terpene found in Rabdosia rubescens, is widely used as dietary
supplement or therapeutic drug, while the effects of oridonin on CYP450 were still unclear …

Role of cytochrome P4501A in biotransformation of the potential anticancer drug oracin

B Szotáková, V Wsól, L Skálová… - … and Toxicologic Pathology, 1999 - Elsevier
Metabolic fate of the potential anticancer drug oracin (I), was studied at microsomal level in
rat using enzyme induction and inhibition. One of the main metabolites arising during …

Research progress and future development potential of oridonin in pharmacological activities

S Ye, S Sun, J Cai, J Jiang - Current Molecular Pharmacology, 2023 - ingentaconnect.com
In recent years, attention has increasingly focused on herbal medicines and their bioactive
components attributed to their multi-target pharmacological activity and low side effects …

Influence of verapamil on the pharmacokinetics of oridonin in rats

J Liu, N Zhang, N Li, X Fan, Y Li - Pharmaceutical biology, 2019 - Taylor & Francis
Context: Oridonin has been traditionally used in Chinese treatment of various cancers, but
its poor bioavailability limits its therapeutic uses. Verapamil can enhance the absorption of …

Identification and comparative oridonin metabolism in different species liver microsomes by using UPLC-Triple-TOF-MS/MS and PCA

Y Ma, W Xie, T Tian, Y Jin, H Xu, K Zhang, Y Du - Analytical biochemistry, 2016 - Elsevier
Oridonin (ORI) is an active natural ent-kaurene diterpenoid ingredient with notable anti-
cancer and anti-inflammation activities. Currently, a strategy was developed to identify …

Inhibitory effects of dioscin on cytochrome P450 enzymes

X Tao, L Zheng, Y Qi, Y Xu, L Xu, L Yin, X Han, K Liu… - RSC Advances, 2014 - pubs.rsc.org
Dioscin, a natural product, shows various pharmacological activities. However, the drug–
drug interaction (DDI) potential of dioscin via the inhibition of cytochrome P450 (CYP) …

Oridonin: a review of its pharmacology, pharmacokinetics and toxicity

X Li, CT Zhang, W Ma, X Xie, Q Huang - Frontiers in pharmacology, 2021 - frontiersin.org
Oridonin, as a natural terpenoids found in traditional Chinese herbal medicine Isodon
rubescens (Hemsl.) H. Hara, is widely present in numerous Chinese medicine preparations …

A comprehensive study of the metabolism of flavonoid oroxin B in vivo and in vitro by UHPLC-Q-TOF-MS/MS

R Feng, X Zhang, J Yin, Y Zhang, Y Ma, X Zhang… - … of Pharmaceutical and …, 2021 - Elsevier
Oroxin B, a flavonoid, is a major bioactive component form Oroxylum indicum (L.) Vent. with
enormous anti-hepatoma effects. To data, the oroxin B metabolism studies remain …