Cytisine, a natural bioactive compound that is mainly isolated from plants of the
Leguminosae family (especially the seeds of Laburnum anagyroides), has been marketed in …

Covering: up to the end of 2011 This review covers classical and modern structural
modifications of the alkaloid, the more recent (since 2007) syntheses of cytisine and …

Cytisine, a natural plant alkaloid, has been marketed in Central and Eastern Europe for over
40 years for the clinical management of smoking cessation. Despite the fact that cytisine has …

Neuronal nicotinic acetylcholine receptors subserve predominantly modulatory roles in the
brain, making them attractive therapeutic targets. Natural products provide key leads in the …

Cigarette smoking is the one of the prevalent risk factors for morbidity in the world. The
treatment of smoking is rapidly changing. Alternative approaches to the nicotine …

Thirty-one N-derivatives of cytisine were prepared in order to modify its pharmacological
profile and to obtain compounds of potential therapeutic interest either at a peripheral or …

Neuronal nicotinic acetylcholine receptors (nAChRs) form a family of ACh-gated cation
channels made up of different subtypes. They are widely distributed in peripheral and …

Cytisine has a molecular structure somewhat similar to that of nicotine and varenicline. The
concept for the new smoking cessation drug varenicline was based partly on cytisine. Like …

Cytisine, an α4β2 nicotinic receptor partial agonist, is a plant alkaloid that is commercially
extracted for use as a smoking cessation medication. Despite its long history of use, there is …

We report the synthesis and pharmacological properties of several cytisine derivatives.
Among them, two 10-substituted derivatives showed much higher selectivities for the α4β2 …