Autoimmune cholestatic liver diseases, including primary biliary cholangitis (PBC) and
primary sclerosing cholangitis (PSC), are manifested as an impairment of normal bile flow …

The gut microbiota has been considered a cornerstone of maintaining the health status of its
human host because it not only facilitates harvesting of nutrients and energy from ingested …

Patients with cholestatic liver diseases like primary sclerosing cholangitis (PSC) and primary
biliary cholangitis (PBC) have a different gut microbiome composition than healthy controls …

Primary sclerosing cholangitis (PSC) is an immune-related cholangiopathy characterized by
biliary inflammation, cholestasis, and multifocal bile duct strictures. It is associated with high …

The gastrointestinal microbiota plays a central role in the host metabolism of bile acids
through deconjugation and dehydroxylation reactions, which generate unconjugated free …

Cholestasis is a condition characterized by the abnormal production or excretion of bile, and
it can be induced by a variety of causes, the factors of which are extremely complex …

Primary bile acids serve important roles in cholesterol metabolism, lipid digestion, host-
microbe interactions, and regulatory pathways in the human host. While most bile acids are …

Background: Increasing data suggests an interaction between bile acids and intestinal
microbiota in the pathogenesis of primary biliary cholangitis (PBC). Bile acid sequestrants …

Bile acid biotransformation is a collaborative effort by the host and the gut microbiome. Host
hepatocytes synthesize primary bile acids from cholesterol. Once these host-derived primary …

The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …