Sophora tonkinensis and active compounds inhibit mitochondrial impairments, inflammation, and LDLR deficiency in myocardial ischemia mice through regulating the …

SN Zhang, Q Liu, XZ Li, WD Yang, Y Zhou - Fitoterapia, 2024 - Elsevier
Ancient Chinese medicine literature and modern pharmacological studies show that
Sophora tonkinensis Gagnep.(ST) has a protective effect on the heart. A biolabel research …

Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling

L Wang, D Yuan, J Zheng, X Wu, J Wang, X Liu, Y He… - Phytomedicine, 2019 - Elsevier
Background Myocardial fibrosis is a common pathological manifestation of many
cardiovascular diseases at the end stage. Autophagy has been demonstrated to play a …

Styrax (Liquidambar orientalis Mill.) promotes mitochondrial function and reduces cardiac damage following myocardial ischemic injury: the role of the AMPK-PGC1α …

F Mu, J Zhao, M Zhao, R Lin, K Liu… - Journal of Pharmacy …, 2023 - academic.oup.com
Objectives To explore the effect of extract of Styrax (ES) on myocardial ischemic injury and
its molecular mechanism, indirectly providing a theoretical basis for the development of ES …

Cardioprotective Effect of Stem-Leaf Saponins From Panax notoginseng on Mice With Sleep Deprivation by Inhibiting Abnormal Autophagy Through PI3K/Akt/mTOR …

Y Cao, Q Li, Y Yang, Z Ke, S Chen, M Li… - Frontiers in …, 2021 - frontiersin.org
Sleep deprivation (SD) may lead to serious myocardial injury in cardiovascular diseases.
Saponins extracted from the roots of Panax notoginseng, a traditional Chinese medicine …

Si-Miao-Yong-An decoction ameliorates cardiac function through restoring the equilibrium of SOD and NOX2 in heart failure mice

Y Ren, X Chen, P Li, H Zhang, C Su, Z Zeng… - Pharmacological …, 2019 - Elsevier
Abstract Si-Miao-Yong-An decoction (SMYAD), a Chinese herbal formula, has been used in
treating ischemic cardiovascular diseases. However, the cardioprotective mechanism of …

Songorine ameliorates LPS-induced sepsis cardiomyopathy by Wnt/β-catenin signaling pathway–mediated mitochondrial biosynthesis

M Chen, S Huang, S Weng, J Weng, R Guo… - Naunyn-Schmiedeberg's …, 2023 - Springer
Septic cardiomyopathy (SCM) is manifested by impairment of cardiac contractile function
with myocardial mitochondrial dysregulation. Natural product, songorine (SGR), a …

The Synergistic Mechanism of Total Saponins and Flavonoids in Notoginseng–Safflower against Myocardial Infarction Using a Comprehensive Metabolomics Strategy

M Fang, Y Meng, Z Du, M Guo, Y Jiang, P Tu, K Hua… - Molecules, 2022 - mdpi.com
Notoginseng and safflower are commonly used traditional Chinese medicines for benefiting
qi and activating blood circulation. A previous study by our group showed that the …

Echinacoside reverses myocardial remodeling and improves heart function via regulating SIRT1/FOXO3a/MnSOD axis in HF rats induced by isoproterenol

Y Ni, J Deng, X Liu, Q Li, J Zhang… - Journal of Cellular …, 2021 - Wiley Online Library
Myocardial remodelling is important pathological basis of HF, mitochondrial oxidative stress
is a promoter to myocardial hypertrophy, fibrosis and apoptosis. ECH is the major active …

Shengxian decoction in chronic heart failure treatment and synergistic property of Platycodonis Radix: a metabolomic approach and its application

F Zhang, Q Zhan, X Dong, B Jiang, L Sun, S Gao… - Molecular …, 2014 - pubs.rsc.org
Shengxian Decoction (SXT), a classic Traditional Chinese Medicine (TCM) prescription,
consists of five TCMs: Astragali Radix, Anemarrhenae Rhizoma, Bupleuri Radix …

Ramulus Mori (Sangzhi) Alkaloids (SZ-A) Ameliorate Myocardial Injury in Type 2 Diabetic Rats by Regulating Autophagy

Y Liu, L Ma, W Xu, X La, B Zhang, J Cui… - Pharmacognosy …, 2024 - journals.sagepub.com
Background Diabetes mellitus (DM) is a persistent metabolic condition resulting from
insufficient insulin or insulin resistance, which gives rise to diverse complications …