Embryonic genome activation (EGA) occurs during preimplantation development and is
characterized by the initiation of de novo transcription from the embryonic genome. Despite …

Emerging evidence highlights the regulatory role of paired-like (PRD-like) homeobox
transcription factors (TFs) in embryonic genome activation (EGA). However, the majority of …

Leucine twenty homeobox (LEUTX) is a paired (PRD)-like homeobox gene that is expressed
almost exclusively in human embryos during preimplantation development. We previously …

The paired-like homeobox transcription factor LEUTX is expressed in human
preimplantation embryos between the 4-and 8-cell stages, and then silenced in somatic …

PAIRED (PRD)-like homeobox genes belong to a class of predicted transcription factor
genes. Several of these PRD-like homeobox genes have been predicted in silico from …

Transcriptional program that drives human preimplantation development is largely unknown.
Here, by using single-cell RNA sequencing of 348 oocytes, zygotes and single blastomeres …

The shift from maternal to embryonic control is a critical developmental milestone in
preimplantation development. Widespread transcriptomic and epigenetic remodeling …

To investigate the contribution of parental genomes to early embryogenesis, we profiled the
single-cell transcriptomes of human biparental and uniparental embryos systematically from …

The trophoblast cell lineage is specified early at the blastocyst stage, leading to the
emergence of the trophectoderm and the pluripotent cells of the inner cell mass. Using a …

The placenta is an essential organ for the fetus, but its regulatory mechanism for formation of
functional trophoblast lineage remains elusive in humans. Although widely known in mice …