In the past decade, the diversity of signals generated by the ubiquitin system has emerged
as a dominant regulator of biological processes and propagation of information in the …

Ubiquitin signals and ubiquitin-binding domains are implicated in almost every cellular
process, but how is their functionality achieved in cells? We assess recent advances in …

Ubiquitin plays an essential role in modulating protein functions, and deregulation of the
ubiquitin system leads to the development of multiple human diseases. Owing to its …

Ubiquitin acts as a versatile cellular signal that controls a wide range of biological processes
including protein degradation, DNA repair, endocytosis, autophagy, transcription, immunity …

The small protein ubiquitin is a central regulator of a cell's life and death. Ubiquitin is best
known for targeting protein destruction by the 26S proteasome. In the past few years …

Ubiquitination regulates nearly all cellular processes by coordinated activity of ubiquitin
writers (E1, E2, and E3 enzymes), erasers (deubiquitinating enzymes) and readers (proteins …

Forty years ago, ubiquitin was first discovered as a posttranslational modification earmarking
proteins for degradation [1]. This seminal, biochemical work laid the foundation for countless …

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by
the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent …

Ubiquitin is best known for its function in targeting proteins for degradation by the
proteasome. Recent studies have revealed several new functions of ubiquitin that are …

Ubiquitylation (also known as ubiquitination) regulates essentially all of the intracellular
processes in eukaryotes through highly specific modification of numerous cellular proteins …