Background Early detection of maladaptive processes underlying pregnancy-related
pathologies is desirable because it will enable targeted interventions ahead of clinical …

Objective Pregnancy is accompanied by dramatic physiological changes in maternal plasma
proteins. Characterization of the maternal plasma proteome in normal pregnancy is an …

Maternal and perinatal morbidity and mortality rates are significantly higher in pregnancies
complicated by preterm labor, pre‐eclampsia and fetal growth restriction. Decades of …

The human plasma proteome is underexplored despite its potential value for monitoring
health and disease. Herein, using a recently developed aptamer-based platform, we profiled …

Elucidation of underlying cellular and molecular mechanisms is pivotal to the
comprehension of biological systems. The successful progression of processes such as …

Background Preterm birth (PTB)(< 37 completed weeks' gestation) is a pathological outcome
of pregnancy and a major global health problem. Babies born preterm have an elevated risk …

Spontaneous preterm birth (sPTB) remains a major clinical dilemma; current diagnostics and
interventions have not reduced the rate of this serious healthcare burden. This study …

Conventional wisdom holds that complications of immature organ systems such as
respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, and …

Motivation Multiple biological clocks govern a healthy pregnancy. These biological
mechanisms produce immunologic, metabolomic, proteomic, genomic and microbiomic …

The molecular mechanisms regulating myometrial contractility and preterm premature
rupture of the membranes leading to preterm birth are poorly understood. The completion of …