Background: Emotional disorders are common comorbid affectations that exacerbate the
severity and persistence of chronic pain. Specifically, depressive symptoms can lead to an …

Background: Depression and pain are both burdensome ailments that affect a major
proportion of the population. It is evident that depression and pain frequently coexist, with …

Background Pain comorbid with depression is frequently encountered in clinical settings
and often leads to significant impaired functioning. Given the complexity of comorbidities, it …

Opinion statement For patients with chronic pain, the experience of pain is intimately linked
with psychologic distress. Epidemiologic studies indicate that depression is a common …

Results from experimental and clinical studies indicate that antidepressants have specific
analgesic properties in chronic pain. The exact site of action of these drugs (spinal or …

The comorbidity of pain and depression has been well established in the literature and is
associated with a greater burden to the individual and society than either condition alone …

Chronic pain afflicts millions of people, commonly causing depression and anxiety. These
conditions must be treated to achieve a good functional outcome from pain treatment …

Introduction: An apparent clinical relationship between pain and depression has long been
recognized, which makes an enormous impact on the individual health care. At present, the …

Depression is a common accompaniment of pain, particularly when pain is unremitting. The
use of a variety of antidepressant medications is associated with pain reduction, an effect …

Chronic pain is both difficult for patients to tolerate and for clinicians to treat effectively. It
differs from other types of pain in etiology and impact, which in turn affects the duration and …