Research Papers

P Gupta - Journal of Family Medicine and Primary Care, 2018 - journals.lww.com
Methods: Ten control and 16 test (10 MG and 6 RP) patients presenting consecutively to the
Pathology Department were selected for the study in July–August 2014. Serum total light …

Serum free light chain analysis in B-cell dyscrasias

I Ramasamy - Annals of Clinical & Laboratory Science, 2007 - Assoc Clin Scientists
Materials and Methods The primary study cohort consisted of 27 IMM (mean age: 75 yr;
range 51–90; 16 M, 11 F) and 54 MGUS (mean age: 74 yr; range: 47–99; 23 F; 31 M) …

Serum free light chain assay and κ/λ ratio performance in patients without monoclonal gammopathies: high false-positive rate

G Singh - American Journal of Clinical Pathology, 2016 - academic.oup.com
Objectives: Serum free light chain assay is a recommended screening test for monoclonal
gammopathies. Anecdotal observations indicated a high rate of false-positive abnormal κ/λ …

[HTML][HTML] Serum free light chain assay and κ/λ ratio: performance in patients with monoclonal gammopathy-high false negative rate for κ/λ ratio

G Singh - Journal of clinical medicine research, 2017 - ncbi.nlm.nih.gov
Background Serum free light chain assay (SFLCA) and κ/λ ratio, and protein electrophoretic
methods are used in the diagnosis and monitoring of monoclonal gammopathies. Methods …

Evaluating the screening value of serum light chain ratio, β2 microglobulin, lactic dehydrogenase and immunoglobulin in patients with multiple myeloma using ROC …

L Ying, X Zhang, N Lu, L Zhao, Y Nie, G Wang… - PLoS …, 2023 - journals.plos.org
Objective Several laboratory and imaging assays are required to diagnose multiple
myeloma (MM). Serum and urine immunofixation electrophoresis are two key assays to …

Assessment of serum free light chain assays for plasma cell disorder screening in a Veterans Affairs population

JM Abadie, DD Bankson - Annals of Clinical & Laboratory …, 2006 - Assoc Clin Scientists
This study evaluated serum κ and λ free light chain (FLC) concentrations in a Veterans
Affairs (VA) population. We hypothesized that our older, mostly male, population should not …

[HTML][HTML] Comparison of serum and urine free light chain analysis in clinical diagnosis

J Cho, DH Lee, G Yoo, J Kim, Y Uh - Blood research, 2022 - synapse.koreamed.org
TO THE EDITOR: Serum protein electrophoresis (sPEP) and serum immunofixation
electrophoresis (sIFE) are the gold standards for diagnosing monoclonal gammopathies …

Clinical specificity of two assays for immunoglobulin kappa and lambda free light chains

CW Farnsworth, B Roemmich, GM Spears… - Clinical Chemistry and …, 2024 - degruyter.com
Objectives Free light chain (FLC) assays and the ratio of κ/λ are recommended for diagnosis,
prognosis and monitoring of plasma cell dyscrasias (PCD). Limited data exists on FLC …

Robust Reference Intervals for Serum Kappa and Lambda Free Light Chains from a Multi Centre Study Population from Hyderabad, India: Myeloma Diagnostic …

N Mohammed, PA Chandran… - Asian Pacific Journal …, 2016 - journal.waocp.org
The International Myeloma Working Group considers the serum free light chain (SFLC)
assay to be an adjunct to traditional tests. Apart from the FLC ratio, the absolute values of …

Limitations of free light chain assays caused by the matrix effect

CW Farnsworth, NM Logsdon, JE Hayes… - The journal of …, 2020 - academic.oup.com
Background Serum free light chain (FLC) assays are used clinically to measure the
concentration of κ and λ FLC in patients with suspected or diagnosed plasma cell …