The use of deuteration in medicinal chemistry has exploded in the past years, and the FDA
has recently approved the first deuterium-labeled drug. Precision deuteration goes beyond …

Selective replacement of hydrogen atoms with deuterium (deuteration) has the unique
benefit of retaining the pharmacologic profile of physiologically active compounds while, in …

Publisher Summary This chapter briefly reviews the use of deuterium to alter the metabolic
properties of compounds and discusses the past and current development of potential …

Deuterium is gaining increased appreciation and utilization as a component of active
pharmaceutical ingredients. Deuteriummodified or-deuterated compounds retain the …

Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one
neutron to a molecule. Despite being a subtle change, this structural modification, known as …

For the longest time, researchers have sought to use deuterium in place of hydrogen in drug
molecules to inhibit metabolic conversion to less active or inactive molecules or to stabilize …

Deuterium, the stable isotope of hydrogen, is known to medicinal chemists for its utility in
mechanistic, spectroscopic, and tracer studies. In fact, well-known applications utilizing …

Objective: Stable heavy isotopes of hydrogen, carbon, and other elements have been
incorporated into drug molecules, largely as tracers for quantitation during the drug …

If the FDA approves Teva Pharmaceutical's deutetrabenazine next month, it will be giving
the first ever green light to a drug containing deuterium, a heavy isotope of hydrogen …

Introduction: Deuterated versions of existing drugs can exhibit improved pharmacokinetic or
toxicological properties due the stronger deuterium–carbon bond modifying their …