Genomic characterization of viral integration sites in HPV‐related cancers

C Bodelon, ME Untereiner, MJ Machiela… - … journal of cancer, 2016 - Wiley Online Library
Persistent infection with carcinogenic human papillomaviruses (HPV) causes the majority of
anogenital cancers and a subset of head and neck cancers. The HPV genome is frequently …

The role of viral integration in the development of cervical cancer

T Yu, MJ Ferber, TH Cheung, TKH Chung… - Cancer genetics and …, 2005 - Elsevier
The development of invasive cervical cancer is associated with human papillomavirus (HPV)
infection and subsequent integration into the host epithelium. More than 99% of cervical …

Human papillomavirus genome integration in squamous carcinogenesis: what have next‐generation sequencing studies taught us?

IJ Groves, N Coleman - The Journal of pathology, 2018 - Wiley Online Library
Human papillomavirus (HPV) infection is associated with∼ 5% of all human cancers,
including a range of squamous cell carcinomas. Persistent infection by high‐risk HPVs …

Non-random integration of the HPV genome in cervical cancer

M Schmitz, C Driesch, L Jansen, IB Runnebaum… - PloS one, 2012 - journals.plos.org
HPV DNA integration into the host genome is a characteristic but not an exclusive step
during cervical carcinogenesis. It is still a matter of debate whether viral integration …

Transcriptionally active regions are the preferred targets for chromosomal HPV integration in cervical carcinogenesis

IK Christiansen, GK Sandve, M Schmitz, M Dürst… - PloS one, 2015 - journals.plos.org
Integration of human papillomavirus (HPV) into the host genome is regarded as a
determining event in cervical carcinogenesis. However, the exact mechanism for integration …

The majority of viral-cellular fusion transcripts in cervical carcinomas cotranscribe cellular sequences of known or predicted genes

I Kraus, C Driesch, S Vinokurova, E Hovig, A Schneider… - Cancer research, 2008 - AACR
Integration of human papillomavirus (HPV) DNA into the host genome is a frequent event in
cervical carcinogenesis and is reported to occur at randomly selected chromosomal sites …

Identification of human papillomavirus type 16 integration sites in high-grade precancerous cervical lesions

M Matovina, I Sabol, G Grubišić, NM Gašperov… - Gynecologic …, 2009 - Elsevier
OBJECTIVES: Infection with oncogenic human papillomaviruses (HPV) is a prerequisite for
the development of cervical cancer. In many cases of cervical cancer and all cervical cancer …

A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques

C Ziegert, N Wentzensen, S Vinokurova, F Kisseljov… - Oncogene, 2003 - nature.com
Persistent infections with high-risk human papillomaviruses (HPVs) induce dysplastic
lesions of the lower genital tract. Some of these lesions eventually progress to invasive …

Dysregulation of host cellular genes targeted by human papillomavirus (HPV) integration contributes to HPV‐related cervical carcinogenesis

R Zhang, C Shen, L Zhao, J Wang… - … Journal of Cancer, 2016 - Wiley Online Library
Integration of human papillomavirus (HPV) viral DNA into the human genome has been
postulated as an important etiological event during cervical carcinogenesis. Several recent …

Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs

A Warburton, TE Markowitz, JP Katz, JM Pipas… - NPJ Genomic …, 2021 - nature.com
Oncogenic human papillomavirus (HPV) genomes are often integrated into host
chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single …