Ellagic acid exerts beneficial effects on hyperuricemia by inhibiting xanthine oxidase and NLRP3 inflammasome activation

ZR Sun, HR Liu, D Hu, MS Fan, MY Wang… - Journal of Agricultural …, 2021 - ACS Publications
Hyperuricemia is a metabolic disease caused by impaired uric acid (UA) metabolism. Ellagic
acid (EA) is a natural small-molecule polyphenolic compound with known antioxidative and …

[HTML][HTML] Antihyperuricemic effect of urolithin A in cultured hepatocytes and model mice

S Adachi, K Sasaki, S Kondo, W Komatsu, F Yoshizawa… - Molecules, 2020 - mdpi.com
Hyperuricemia is defined as a disease with high uric acid (UA) levels in the blood and a
strong risk factor for gout. Urolithin A (UroA) is a main microbial metabolite derived from …

Hypouricemic effect of gallic acid, a bioactive compound from Sonneratia apetala leaves and branches, on hyperuricemic mice

L Jiang, Y Wu, C Qu, Y Lin, X Yi, C Gao, J Cai, Z Su… - Food & function, 2022 - pubs.rsc.org
As a tropical medicinal plant, Sonneratia apetala is mainly distributed in the southeast
coastal areas of China. Recently, the hypouricemic effect of Sonneratia apetala leaves and …

Naringenin ameliorates hyperuricemia by regulating renal uric acid excretion via the PI3K/AKT signaling pathway and renal inflammation through the NF-κB signaling …

B Yang, M Xin, S Liang, Y Huang, J Li… - Journal of Agricultural …, 2022 - ACS Publications
Hyperuricemia characterized by high serum levels of uric acid (UA,> 6.8 mg/dL) is regarded
as a common chronic metabolic disease. When used as a food supplement, naringenin …

Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice

JX Zhu, HY Yang, WQ Hu, J Cheng, Y Liu, LT Yi… - …, 2021 - Springer
Lagotis brachystachya Maxim is a herb widely used in traditional Tibetan medicine. Our
previous study indicated that total extracts from Lagotis brachystachya could lower uric acid …

Isoorientin exerts a urate-lowering effect through inhibition of xanthine oxidase and regulation of the TLR4-NLRP3 inflammasome signaling pathway

MF An, MY Wang, C Shen, ZR Sun, YL Zhao… - Journal of natural …, 2021 - Springer
Isoorientin (ISO), a natural flavonoid compound, has been identified in several plants and its
biological activity is determined and the study on lowering uric acid has not been reported …

[HTML][HTML] Anti-hyperuricemia effect of hesperetin is mediated by inhibiting the activity of xanthine oxidase and promoting excretion of uric acid

MF An, C Shen, SS Zhang, MY Wang, ZR Sun… - Frontiers in …, 2023 - frontiersin.org
Hesperetin is a natural flavonoid with many biological activities. In view of hyperuricemia
treatment, the effects of hesperetin in vivo and in vitro, and the underlying mechanisms, were …

Sonneratia apetala seed oil attenuates potassium oxonate/hypoxanthine-induced hyperuricemia and renal injury in mice

J Chen, L Xu, L Jiang, Y Wu, L Wei, X Wu, S Xiao… - Food & Function, 2021 - pubs.rsc.org
Sonneratia apetala seeds are considered as prospective nutraceuticals with a high content
of unsaturated fatty acids (UFAs) which are mainly distributed in the oil. It is well-known that …

Anti-hyperuricemic and nephroprotective effect of geniposide in chronic hyperuricemia mice

C Liu, H Zhou, R Zhang, X Wang, S He, J Zhang… - Journal of Functional …, 2019 - Elsevier
Hyperuricemia is a key risk factor for kidney disease. Geniposide possesses various
pharmacological activities, however, to our knowledge, no previous work investigated the …

Antihyperuricemic effect of liquiritigenin in potassium oxonate-induced hyperuricemic rats

L Hongyan, W Suling, Z Weina, Z Yajie, R Jie - Biomedicine & …, 2016 - Elsevier
The aim is to investigate the anti-hyperuricemic and renal protective effects of liquiritigenin in
potassium oxonate-induced hyperuricemic rats. Hyperuricemia in rats was induced were …