BACKGROUND: Irritable bowel syndrome (IBS) is the most common functional bowel
disorder and has a strong predominance in women. Recent data suggest that the brain may …

Abstract Serotonin (5‐HT) plays an important role in the pathophysiology of irritable bowel
syndrome (IBS). Using α‐[11C] methyl‐l‐tryptophan‐positron emission tomography (PET), it …

Background Alterations in serotonin (5‐HT) metabolism have been postulated to play a role
in the pathogenesis of irritable bowel syndrome (IBS). However, previous reports regarding …

Background: Serotonin (5-HT) may play an important role in the regulation of colonic motility
in humans. However, it is not known whether alterations in the colonic 5-HT system are …

Background & Aims: 5-hydroxytryptamine-3 (5-HT3) receptor antagonists improve symptoms
in patients with diarrhea-predominant irritable bowel syndrome (D-IBS), 5-HT4 agonists help …

OBJECTIVES: Serotonin (5-hydroxytryptamine, 5-HT) metabolism may be altered in gut
disorders, including in the irritable bowel syndrome (IBS). We assessed in patients with IBS …

Efforts to define either a biomarker for irritable bowel syndrome (IBS) or a valid animal model
have proven disappointing. The aims of this study were to determine if buspirone stimulates …

Abstract Background Altered serotonergic (5‐HT) metabolism and visceral perception have
been associated with the pathogenesis of irritable bowel syndrome (IBS). Aim of this …

Background—Increased concentrations of 5-hydroxytryptamine (5-HT) can be detected in
the systemic circulation after a meal and may be involved in the physiological control of …

POLISH ARCHIVES OF INTERNAL MEDICINE 2018; 128 (11) 712 constipation. In IBS‑D, 5‑
HT3 receptor antag‑onists have been used; however, due to serious side effects, their …