As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the
brain parenchyma and blood, and modulates communication between the brain and blood …

Diabetes mellitus (DM) is a disorder due to the inability properly to metabolize glucose
associated with dysregulation of metabolic pathways of lipids and proteins resulting in …

Diabetes mellitus (DM) is one of the most common diseases in the world. Among its effects
are an increase in the risk of cognitive impairment, including Alzheimer's disease, and blood …

Hyperglycemic conditions are prodromal to blood-brain barrier (BBB) impairment. The BBB
comprises cerebral microvessel endothelial cells (CMECs) that are surrounded by astrocytic …

The blood–brain barrier, formed by specialized brain endothelial cells that are
interconnected by tight junctions, strictly regulates paracellular permeability to maintain an …

Diabetes-related cognitive dysfunction has been recognized for many years in humans, but
the pathogenesis of this condition is poorly understood. Evidence from animal studies …

Background This is an exploratory study using a novel imaging modality, quantitative
ultrashort time-to-echo, contrast enhanced (QUTE-CE) magnetic resonance imaging to …

Diabetic insulin resistance and pro-diabetic diet are reported to increase dementia risk
through unknown mechanisms. Emerging evidence suggests that the integrity of blood-brain …

Vascular pathology is recognized as a principle insult in type 2 diabetes mellitus (T2DM). Co‐
morbidities such as structural brain abnormalities, cognitive, learning and memory deficits …

Diabetes mellitus is associated with cognitive impairment and various central nervous
system pathologies such as stroke, vascular dementia, or Alzheimer's disease. The exact …