Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their
inhibitors control matrix turnover and function. Recent advances in our understanding of …

Controlling degradation of the extracellular matrix is crucial in arthritic diseases such as
osteoarthritis (OA) and rheumatoid arthritis (RA), as conventional treatments do not …

Irreversible degradation of articular cartilage is a major feature of the arthritides, and its
prevention is a therapeutic goal which has been difficult to achieve. Enzymes from the matrix …

The matrix metalloproteinases (MMPs) are a unique family of metalloenzymes, which, once
activated, can destroy all the components of cartilage. MMPs are found in resorbing …

Summary Introduction Matrix metalloproteinases (MMPs) and 'aggrecanase'a disintegrin
and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play …

The debilitating destruction of joint tissues seen in osteoarthritis (OA) is due, in large part, to
the degradative activity of metalloproteinase (MP) enzymes that target extracellular matrix …

Imbalance in the expression of matrix metalloproteinases and their inhibitors contribute
considerably to abnormal connective tissue degradation prevalent in various orthopaedic …

Abstract Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM)
and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc …

A role for metalloproteinases in the pathological destruction in diseases such as rheumatoid
arthritis and osteoarthritis, and the irreversible nature of the ensuing cartilage and bone …

The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …