Folate is vital for fetal development. Periconceptional folic acid supplementation and food
fortification are recommended to prevent neural tube defects. Mechanisms whereby …

Background It has been proposed that maternal folic-acid supplement use may alter the
DNA-methylation patterns of the offspring during the in-utero period, which could influence …

Background Emerging evidence suggests that maternal folate status can impact cognitive
development in childhood. Folate-dependent DNA methylation may provide a biological …

The clinical significance of periconceptional folic acid supplementation (FAS) in the
prevention of neonatal neural tube defects (NTDs) has been recognized for decades …

Epigenetic mechanisms are proposed to link maternal concentrations of methyl group donor
nutrients with the risk of low birth weight. However, empirical data are lacking. We have …

Supplementation with folic acid during pregnancy is known to reduce the risk of neural tube
defects and low birth weight. It is thought that folate and other one-carbon intermediates …

Folic acid supplementation during pregnancy has known beneficial effects. It reduces risk of
neural tube defects and low birth weight. Folate and other one-carbon intermediates might …

There is growing evidence that epigenetic dysregulation plays a role in neurodevelopmental
disorders. In humans, folate is one of the main donors of the methyl group required for the …

DNA methylation is one of several epigenetic mechanisms that play a regulatory role in
genome programming and imprinting during embryogenesis. Aberrant DNA methylation has …

Birthweight is associated with health outcomes across the life course, DNA methylation may
be an underlying mechanism. In this meta-analysis of epigenome-wide association studies …