Y-box-binding protein 1 (YB-1) and its functions

IA Eliseeva, ER Kim, SG Guryanov… - Biochemistry …, 2011 - Springer
This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

[HTML][HTML] Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

PK Maurya, A Mishra, BS Yadav, S Singh… - Journal of …, 2017 - ncbi.nlm.nih.gov
The Y-box binding protein (YB-1) is known to be a multifunctional transcription and
translation factor during expression of several proteins. It is a vital oncoprotein that regulates …

YB-1: oncoprotein, prognostic marker and therapeutic target?

A Lasham, CG Print, AG Woolley, SE Dunn… - Biochemical …, 2013 - portlandpress.com
Hanahan and Weinberg have proposed the 'hallmarks of cancer'to cover the biological
changes required for the development and persistence of tumours [Hanahan and Weinberg …

[HTML][HTML] YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy

Q Yin, M Zheng, Q Luo, D Jiang, H Zhang, C Chen - Cells, 2022 - mdpi.com
Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …

[HTML][HTML] YB-1 as a cell cycle-regulated transcription factor facilitating cyclin A and cyclin B1 gene expression

K Jurchott, S Bergmann, U Stein, W Walther… - Journal of Biological …, 2003 - ASBMB
Expression of the Y-box protein YB-1 is increased in proliferating normal and cancer cells,
but its role in cell proliferation and cell cycle progression is unclear. We have identified a cell …

Role of the human Y box-binding protein YB-1 in cellular sensitivity to the DNA-damaging agents cisplatin, mitomycin C, and ultraviolet light

T Ohga, K Koike, M Ono, Y Makino, Y Itagaki… - Cancer research, 1996 - AACR
The Y box-binding protein (YB-1) binds to DNA sequences, present in the control regions of
many genes, that contain an inverted CCAAT box. The binding activity of a nuclear factor …

Y-box binding protein 1–a prognostic marker and target in tumour therapy

C Kosnopfel, T Sinnberg, B Schittek - European journal of cell biology, 2014 - Elsevier
Y-box binding protein 1 (YB-1) is a multifunctional protein involved in various cellular
processes including both transcriptional and translational regulation of target gene …

A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance

A Alkrekshi, W Wang, PS Rana, V Markovic… - Cellular signalling, 2021 - Elsevier
The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain
protein family with multifunctional properties both in the cytoplasm and inside the nucleus …

The increased expression of Y box‐binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance

B Schittek, K Psenner, B Sauer, F Meier… - … journal of cancer, 2007 - Wiley Online Library
In previous studies we identified the transcription/translation factor Y‐box‐binding protein
(YB‐1) as a gene that is upregulated in primary melanoma and melanoma metastases when …

YB‐1 protein: functions and regulation

DN Lyabin, IA Eliseeva… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
The Y‐box binding protein 1 (YB‐1, YBX1) is a member of the family of DNA‐and RNA‐
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …