[HTML][HTML] 3-Iodothyronamine Affects Thermogenic Substrates' Mobilization in Brown Adipocytes

M Gencarelli, A Laurino, E Landucci, D Buonvicino… - Biology, 2020 - mdpi.com
We investigated the effect of 3-iodothyronamine (T1AM) on thermogenic substrates in brown
adipocytes (BAs). BAs isolated from the stromal fraction of rat brown adipose tissue were …

Potent thermogenic action of triiodothyroacetic acid in brown adipocytes

G Medina-Gomez, A Hernandez, RM Calvo… - Cellular and Molecular …, 2003 - Springer
Triiodothyroacetic acid (TRIAC) is a triiodothyronine (T3) metabolite with high affinity for T3
nuclear receptors. We compared the thermogenic action of TRIAC versus T3 in brown …

Triiodothyronine regulates distribution of thyroid hormone receptors by activating AMP-activated protein kinase in 3T3-L1 adipocytes and induces uncoupling protein …

CZ Wang, D Wei, MP Guan, YM Xue - Molecular and cellular biochemistry, 2014 - Springer
The purposes of this study were to examine whether thermogenesis in 3T3-L1 adipocytes is
related to variations in thyroid hormone receptors (TRs) that are differently regulated by …

[HTML][HTML] Control of adipocyte thermogenesis and lipogenesis through β3-adrenergic and thyroid hormone signal integration

A Guilherme, B Yenilmez, AH Bedard, F Henriques… - Cell reports, 2020 - cell.com
Here, we show that β adrenergic signaling coordinately upregulates de novo lipogenesis
(DNL) and thermogenesis in subcutaneous white adipose tissue (sWAT), and both effects …

Thermogenic effect of triiodothyroacetic acid at low doses in rat adipose tissue without adverse side effects in the thyroid axis

G Medina-Gomez, RM Calvo… - American Journal of …, 2008 - journals.physiology.org
Triiodothyroacetic acid (TRIAC) is a physiological product of triiodothyronine (T3)
metabolism, with high affinity for T3 nuclear receptors. Its interest stems from its potential …

[HTML][HTML] 3, 5-Diiodo-L-thyronine activates brown adipose tissue thermogenesis in hypothyroid rats

A Lombardi, R Senese, R De Matteis, RA Busiello… - PLoS …, 2015 - journals.plos.org
3, 5-diiodo-l-thyronine (T2), a thyroid hormone derivative, is capable of increasing energy
expenditure, as well as preventing high fat diet-induced overweight and related metabolic …

Second messenger signaling mechanisms of the brown adipocyte thermogenic program: an integrative perspective

F Shi, S Collins - Hormone molecular biology and clinical …, 2017 - degruyter.com
Abstract β-adrenergic receptors (βARs) are well established for conveying the signal from
catecholamines to adipocytes. Acting through the second messenger cyclic adenosine …

Tyrosol May Prevent Obesity by Inhibiting Adipogenesis in 3T3‐L1 Preadipocytes

F Pacifici, CLA Farias, S Rea, B Capuani… - Oxidative medicine …, 2020 - Wiley Online Library
Tyrosol (TR), a major polyphenol found in extra virgin olive oil (EVOO), exerts several
antioxidant effects. However, only scarce evidences are present regarding its activity on …

Glucocorticoids decrease thermogenic capacity and increase triacylglycerol synthesis by glycerokinase activation in the brown adipose tissue of rats

AP Assis, KE Silva, N Lautherbach, HJN Morgan… - Lipids, 2022 - Wiley Online Library
Although it is well established that glucocorticoids inactivate thermogenesis and promote
lipid accumulation in interscapular brown adipose tissue (IBAT), the underlying mechanisms …

Browning deficiency and low mobilization of fatty acids in gonadal white adipose tissue leads to decreased cold-tolerance of transglutaminase 2 knock-out mice

A Mádi, I Cuaranta-Monroy, K Lénárt, A Pap… - … et Biophysica Acta (BBA …, 2017 - Elsevier
During cold-exposure 'beige'adipocytes with increased mitochondrial content are activated
in white adipose tissue (WAT). These cells, similarly to brown adipose tissue (BAT) …