Mitochondrial stress and dysfunction play important roles in many pathologies. However,
how cells respond to mitochondrial stress is not fully understood. Here, we examined the …

Protein synthesis is critically dependent on transfer (t)-RNAs, but the factors regulating tRNA
function are poorly understood. In this issue of Cell Metabolism, Wei et al.(2015) show that …

tRNA (tRNA) is a key molecule used for protein synthesis, with multiple points of stress-
induced regulation that can include transcription, transcript processing, localization and …

Mitochondria are dynamic organelles in cellular metabolism and physiology. Mitochondrial
DNA (mtDNA) mutations are associated with a broad spectrum of clinical abnormalities …

A subset of mitochondrial tRNAs (mt-tRNAs) contains taurine-derived modifications at 34U of
the anticodon. Loss of taurine modification has been linked to the development of …

Maintenance of mitochondrial gene expression is crucial for cellular homeostasis. Stress
conditions may lead to a temporary reduction of mitochondrial genome copy number, raising …

Transfer RNAs (tRNAs) contain a wide variety of posttranscriptional modifications that are
important for accurate decoding. Mammalian mitochondrial tRNAs (mt-tRNAs) are modified …

Maintenance of the mitochondrial thiol redox state is essential for cell survival. However, we
lack a comprehensive understanding of the redox response to mitochondrial glutathione …

To gain a wider view of the pathways that regulate mitochondrial function, we combined the
effect of heat stress on respiratory capacity with the discovery potential of a genome-wide …

Mitochondrial stress, resulting from dysfunction and proteostasis disturbances, triggers the
mitochondrial unfolded protein response (UPRMT), which activates gene encoding …