Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Protein aggregation is a hallmark of neurodegenerative diseases. However, the mechanism
that induces pathogenic aggregation is not well understood. Recently, it has emerged that …

Liquid-liquid phase separation of RNA-binding proteins mediates the formation of numerous
membraneless organelles with essential cellular function. However, aberrant phase …

Protein misfolding is common to most neurodegenerative diseases, including Alzheimer's
and Parkinson's diseases. Recent work using animal models with intracellular α-synuclein …

Phase separation of biomolecules leading to the formation of assemblies with distinct
material properties has recently emerged as a new paradigm underlying subcellular …

A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …

Cellular deposition of protein aggregates, one of the hallmarks of neurodegeneration,
disrupts cellular functions and leads to neuronal death. Mutations, posttranslational …

Amyloid aggregation of α-synuclein (αS) is the hallmark of Parkinson's disease and other
synucleinopathies. Recently, Tau protein, generally associated with Alzheimer's disease …

Neuropathological aggregates of the intrinsically disordered microtubule-associated protein
Tau are hallmarks of Alzheimer's disease, with decades of research devoted to studying the …

Biomolecular condensation via liquid–liquid phase separation (LLPS) of intrinsically
disordered proteins/regions (IDPs/IDRs), with and without nucleic acids, has drawn …