Chlorin e6-induced photodynamic effect facilitates immunogenic cell death of lung cancer as a result of oxidative endoplasmic reticulum stress and DNA damage

TT Yu, J Hu, QR Li, XC Peng, HZ Xu, N Han… - International …, 2023 - Elsevier
Suppression of the immune microenvironment is an important endogenous contributor to
treatment failure in lung cancer. Photodynamic therapy (PDT) is widely used in the treatment …

[HTML][HTML] Photodynamic-therapy activates immune response by disrupting immunity homeostasis of tumor cells, which generates vaccine for cancer therapy

Y Zheng, G Yin, V Le, A Zhang, S Chen… - … journal of biological …, 2016 - ncbi.nlm.nih.gov
Photodynamic therapy (PDT), a regulatory approved cancer treatment, is reported to be
capable of causing immunogenic apoptosis. The current data reveal PDT can cause the …

Low dose photodynamic-therapy induce immune escape of tumor cells in a HIF-1α dependent manner through PI3K/Akt pathway

J Wan, W Wu, Y Che, N Kang, RQ Zhang - International …, 2015 - Elsevier
As a regulatory approved antitumor therapy, photodynamic therapy (PDT) shows poor effect
in clinical application. The current study aimed at investigating the mechanism through …

Phototherapeutic Induction of Immunogenic Cell Death and CD8+ T Cell-Granzyme B Mediated Cytolysis in Human Lung Cancer Cells and Organoids

A Valančiūtė, L Mathieson, RA O'Connor, JI Scott… - Cancers, 2022 - mdpi.com
Simple Summary Immunogenic cancer cell death and photodynamic therapy play an
important emerging role in cancer treatment. Understanding mechanisms involved in tumor …

[HTML][HTML] The role of photodynamic therapy in triggering cell death and facilitating antitumor immunology

L Tan, X Shen, Z He, Y Lu - Frontiers in Oncology, 2022 - frontiersin.org
Cancer is a major threat to human health because of its high mortality, easy recurrence,
strong invasion and metastasis. Photodynamic therapy (PDT) is one of the most promising …

Chlorin e6 mediated photodynamic therapy triggers resistance through ATM-related DNA damage response in lung cancer cells

QL Ma, MO Shen, N Han, HZ Xu, XC Peng… - Photodiagnosis and …, 2022 - Elsevier
Objective Photodynamic therapy (PDT) is a promising strategy for the treatment of malignant
tumors due to its high selectivity, limited-toxicity, and non-invasiveness. However, PDT can …

Chlorin e6-induced photodynamic effect polarizes the macrophage into an M1 phenotype through oxidative DNA damage and activation of STING

TT Yu, N Han, LG Li, XC Peng, QR Li, HZ Xu… - Frontiers in …, 2022 - frontiersin.org
The tumor-associated macrophage (TAM) serves as an immunosuppressive agent in the
malignant tumor microenvironment, facilitating the development and metastasis of lung …

Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding

L Jia, Y Hong, X He, Y Zhou, L Ren, H Du, B Zhao… - Chinese Chemical …, 2024 - Elsevier
Innovative anti-cancer therapies that activate the immune system show promise in
combating cancers resistant to conventional treatments. Photodynamic therapy (PDT) is one …

Which cell death modality wins the contest for photodynamic therapy of cancer?

T Mishchenko, I Balalaeva, A Gorokhova… - Cell death & …, 2022 - nature.com
Photodynamic therapy (PDT) was discovered more than 100 years ago. Since then, many
protocols and agents for PDT have been proposed for the treatment of several types of …

A novel photodynamic therapy targeting cancer cells and tumor-associated macrophages

N Hayashi, H Kataoka, S Yano, M Tanaka… - Molecular cancer …, 2015 - AACR
Tumor-associated macrophages (TAM) in cancer stroma play important roles for cancer cell
growth, invasion, angiogenesis, and metastases. We synthesized a novel photosensitizer …