[HTML][HTML] 22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma cells by inhibiting MMP-9 activity and MAPK signaling

ESP Aranha, AJ de Sousa Portilho, LB de Sousa… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance 22β-hydroxytingenone (22-HTG) is a
quinonemethide triterpene isolated from Salacia impressifolia (Miers) AC Smith (family …

[HTML][HTML] 22β-hydroxytingenone reduces proliferation and invasion of human melanoma cells

ESP Aranha, EL da Silva, FP Mesquita, LB de Sousa… - Toxicology in Vitro, 2020 - Elsevier
Melanoma is a skin cancer with high invasive potential and high lethality. Considering that
quinonemethide triterpenes are described as promising anticancer agents, the aim of this …

The Inhibitory Effect of 3β‐Hydroxy‐12‐oleanen‐27‐oic Acid on Growth and Motility of Human Hepatoma HepG2 Cells through JNK and Akt Signaling Pathway

J Wang, X Chen, Z Zhou, J Li… - … and Alternative Medicine, 2013 - Wiley Online Library
3β‐Hydroxy‐12‐oleanen‐27‐oic acid (ATA) was a main antitumor active triterpene from the
rhizomes of Astilbe chinensis. In this study, we investigated its effects on growth, apoptosis …

[HTML][HTML] Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38 …

ACBC Rodrigues, LM Bomfim, SP Neves… - Biomedicine & …, 2021 - Elsevier
Acute myeloid leukemia (AML) is the most lethal form of leukemia. Standard anti-AML
treatment remains almost unchanged for decades. Tingenone (TG) and 22 …

The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro

B Cevatemre, B Botta, M Mori, S Berardozzi… - Chemico-Biological …, 2016 - Elsevier
Despite the rapid advances in chemotherapy regimens, the outcome of patients with breast
cancer is not satisfactory. One of the reasons of this dissatisfaction is that subsets of cells in …

Trichosanthes kirilowii Ethanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis through Inhibition of STAT3 Activity in Breast Cancer Cells

SR Kim, HS Seo, HS Choi, SG Cho… - Evidence‐Based …, 2013 - Wiley Online Library
Trichosanthes kirilowii tuber is a traditional medicine which exhibits various medicinal
effects including antidiabetic and anticancer activities in several cancer cells. Recently, it …

Bioactive compound 1, 8-Cineole selectively induces G2/M arrest in A431 cells through the upregulation of the p53 signaling pathway and molecular docking studies

S Sampath, S Subramani, S Janardhanam… - Phytomedicine, 2018 - Elsevier
Background Callistemon citrinus has been traditionally known for its medicinal property.
Recently, our research group identified 1, 8-Cineole, as one of the predominant compound …

Tanshinol inhibits growth of malignant melanoma cells via regulating miR-1207-5p/CHPF pathway

Y Wang, D Zhang - Archives of Dermatological Research, 2020 - Springer
Tanshinol possesses anti-tumor activity in melanoma both in vitro and in vivo, and miR-1207-
5p is involved in tumor progression in melanoma. However, whether miR-1207-5p can be …

Low concentrations of trichosanthin induce apoptosis and cell cycle arrest via c‑Jun N‑terminal protein kinase/mitogen‑activated protein kinase activation

D Zhang, B Chen, J Zhou, L Zhou… - Molecular …, 2015 - spandidos-publications.com
Trichosanthin (TCS) is a type I ribosome‑inactivating protein, which inhibits cell viability in
human epithelial type 2 (HEp‑2) and AMC‑HN‑8 human laryngeal epidermoid carcinoma …

Evidence of γ-Tocotrienol as an Apoptosis-Inducing, Invasion-Suppressing, and Chemotherapy Drug-Sensitizing Agent in Human Melanoma Cells

PN Chang, WN Yap, DT Wing Lee, MT Ling… - Nutrition and …, 2009 - Taylor & Francis
To date, the most effective cure for metastatic melanoma remains the surgical resection of
the primary tumor. Recently, tocotrienol-rich-fraction has shown antiproliferative effect on …