Mitochondria and mitochondrial ROS in cancer: novel targets for anticancer therapy
Y Yang, S Karakhanova, W Hartwig… - Journal of cellular …, 2016 - Wiley Online Library
Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell
signaling. Mitochondria in malignant cells differ structurally and functionally from those in …
signaling. Mitochondria in malignant cells differ structurally and functionally from those in …
Mitochondria in cancer: in the aspects of tumorigenesis and targeted therapy
N Badrinath, SY Yoo - Carcinogenesis, 2018 - academic.oup.com
Mitochondria play pivotal roles in most eukaryotic cells, ranging from energy production to
regulation of apoptosis. As sites of cellular respiration, mitochondria experience …
regulation of apoptosis. As sites of cellular respiration, mitochondria experience …
Mitochondrial dysfunction at the center of cancer therapy
HY Chiu, EXY Tay, DST Ong… - Antioxidants & redox …, 2020 - liebertpub.com
Significance: Mitochondria undergo constant morphological changes through fusion, fission,
and mitophagy. As the key organelle in cells, mitochondria are responsible for numerous …
and mitophagy. As the key organelle in cells, mitochondria are responsible for numerous …
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?
SS Sabharwal, PT Schumacker - Nature Reviews Cancer, 2014 - nature.com
Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism,
biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated …
biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated …
Mitochondria as cancer drug targets
Cancer cells are defined by their unlimited replicative potential and resistance to cell death
stimuli. It is generally considered that a point of no return in apoptotic cell death is the …
stimuli. It is generally considered that a point of no return in apoptotic cell death is the …
Mitochondria as targets for cancer therapy
SJ Ralph, J Neuzil - Mitochondria and cancer, 2009 - Springer
Treatments that selectively target and kill cancer cells without affecting normal cells would
represent the panacea for cancer. Gleevec (Imatinib) treatment of chronic myelogenous …
represent the panacea for cancer. Gleevec (Imatinib) treatment of chronic myelogenous …
[HTML][HTML] Mitochondria deregulations in cancer offer several potential targets of therapeutic interventions
C Musicco, A Signorile, V Pesce… - International Journal of …, 2023 - mdpi.com
Mitochondria play a key role in cancer and their involvement is not limited to the production
of ATP only. Mitochondria also produce reactive oxygen species and building blocks to …
of ATP only. Mitochondria also produce reactive oxygen species and building blocks to …
[HTML][HTML] Mitochondria targeting as an effective strategy for cancer therapy
Mitochondria are well known for their role in ATP production and biosynthesis of
macromolecules. Importantly, increasing experimental evidence points to the roles of …
macromolecules. Importantly, increasing experimental evidence points to the roles of …
Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger
SJ Ralph, S Rodríguez-Enríquez, J Neuzil… - Molecular aspects of …, 2010 - Elsevier
Mitochondria are emerging as idealized targets for anti-cancer drugs. One reason for this is
that although these organelles are inherent to all cells, drugs are being developed that …
that although these organelles are inherent to all cells, drugs are being developed that …
[HTML][HTML] Mitocans revisited: mitochondrial targeting as efficient anti-cancer therapy
Mitochondria are essential cellular organelles, controlling multiple signalling pathways
critical for cell survival and cell death. Increasing evidence suggests that mitochondrial …
critical for cell survival and cell death. Increasing evidence suggests that mitochondrial …