Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell
signaling. Mitochondria in malignant cells differ structurally and functionally from those in …

Mitochondria play pivotal roles in most eukaryotic cells, ranging from energy production to
regulation of apoptosis. As sites of cellular respiration, mitochondria experience …

Significance: Mitochondria undergo constant morphological changes through fusion, fission,
and mitophagy. As the key organelle in cells, mitochondria are responsible for numerous …

Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism,
biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated …

Cancer cells are defined by their unlimited replicative potential and resistance to cell death
stimuli. It is generally considered that a point of no return in apoptotic cell death is the …

Treatments that selectively target and kill cancer cells without affecting normal cells would
represent the panacea for cancer. Gleevec (Imatinib) treatment of chronic myelogenous …

Mitochondria play a key role in cancer and their involvement is not limited to the production
of ATP only. Mitochondria also produce reactive oxygen species and building blocks to …

Mitochondria are well known for their role in ATP production and biosynthesis of
macromolecules. Importantly, increasing experimental evidence points to the roles of …

Mitochondria are emerging as idealized targets for anti-cancer drugs. One reason for this is
that although these organelles are inherent to all cells, drugs are being developed that …

Mitochondria are essential cellular organelles, controlling multiple signalling pathways
critical for cell survival and cell death. Increasing evidence suggests that mitochondrial …