Role of microRNA-502-3p in human diseases

D Devara, Y Choudhary, S Kumar - Pharmaceuticals, 2023 - mdpi.com
MicroRNAs (miRNAs) are non-coding RNAs that play a major role in gene regulation in
several diseases. MicroRNA-502-3p (MiR-502-3p) has been previously characterized in a …

MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons

B Sharma, MM Torres, S Rodriguez… - Neural Regeneration …, 2024 - journals.lww.com
Gamma-aminobutyric acid (GABA) ergic neurons, the most abundant inhibitory neurons in
the human brain, have been found to be reduced in many neurological disorders, including …

Human microRNA (miR-20b-5p) modulates Alzheimer's disease pathways and neuronal function, and a specific polymorphism close to the MIR20B gene influences …

R Wang, N Chopra, K Nho, B Maloney… - Molecular …, 2022 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with loss of cognitive,
executive, and other mental functions, and is the most common form of age-related …

[HTML][HTML] Regulatory roles of the miR-200 family in neurodegenerative diseases

J Fu, L Peng, T Tao, Y Chen, Z Li, J Li - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Neurodegenerative diseases are chronic and progressive disorders which are not effectively
treated through adopting conventional therapies. For this unmet medical need, alternative …

miR-30a-5p induces Aβ production via inhibiting the nonamyloidogenic pathway in Alzheimer's disease

T Sun, K Zhao, M Liu, Z Cai, L Zeng, J Zhang… - Pharmacological …, 2022 - Elsevier
Alzheimer's disease (AD) pathogenesis is known to involve a dysregulation of microRNA
expression, and these intricate transcriptional cascades between multiple pathological …

The potential role of miR-124-3p in tumorigenesis and other related diseases

Q Li, S Liu, J Yan, MZ Sun, FT Greenaway - Molecular Biology Reports, 2021 - Springer
MicroRNAs (miRNAs) are a class of single‐stranded noncoding and endogenous RNA
molecules with a length of 18–25 nucleotides. Previous work has shown that miR-124-3p …

MicroRNA-125a-3p Modulate Amyloid β-Protein through the MAPK Pathway in Alzheimer's Disease

XC Zhu, MZ Zhu, J Lu, QY Yao, JW Hu… - Current Alzheimer …, 2023 - ingentaconnect.com
Background: MicroRNA (miR)-125a-3p is reported to play an important role in some central
nervous system diseases, such as Alzheimer's disease (AD). However, a study has not been …

MicroRNA-107 prevents amyloid-β-induced neurotoxicity and memory impairment in mice

B Shu, X Zhang, G Du, Q Fu… - … journal of molecular …, 2018 - spandidos-publications.com
The pathogenesis of Alzheimer's disease (AD) has still not been fully elucidated, however it
is thought that the build up of amyloid plaque at least partially causes the symptoms of AD …

[HTML][HTML] MicroRNA‑26b is upregulated in a double transgenic mouse model of Alzheimer's disease and promotes the expression of amyloid‑β by targeting insulin‑like …

H Liu, W Chu, L Gong, X Gao… - Molecular Medicine …, 2016 - spandidos-publications.com
Alzheimer's disease (AD) is the most common form of dementia among the aging
population. It is pathologically characterized by synaptic impairment, accumulation of …

MicroRNA‐128 suppresses tau phosphorylation and reduces amyloid‐beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's …

S Li, CH Poon, Z Zhang, M Yue, R Chen… - CNS Neuroscience …, 2023 - Wiley Online Library
Abstract Introduction and Aims Alzheimer's disease (AD) is characterized by the abnormal
accumulation of hyperphosphorylated tau proteins and amyloid‐beta (Aβ) peptides. Recent …