[HTML][HTML] Brain-derived neurotrophic factor (BDNF) role in cannabinoid-mediated neurogenesis

FF Ferreira, FF Ribeiro, RS Rodrigues… - Frontiers in cellular …, 2018 - frontiersin.org
The adult mammalian brain can produce new neurons in a process called adult
neurogenesis, which occurs mainly in the subventricular zone (SVZ) and in the hippocampal …

[HTML][HTML] Interaction between cannabinoid type 1 and type 2 receptors in the modulation of subventricular zone and dentate gyrus neurogenesis

RS Rodrigues, FF Ribeiro, F Ferreira, SH Vaz… - Frontiers in …, 2017 - frontiersin.org
Neurogenesis in the adult mammalian brain occurs mainly in two neurogenic niches, the
subventricular zone (SVZ) and the subgranular zone (SGZ) of the dentate gyrus (DG) …

[HTML][HTML] Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures

S Xapelli, F Agasse, L Sarda-Arroyo, L Bernardino… - PloS one, 2013 - journals.plos.org
The endocannabinoid system has been implicated in the modulation of adult neurogenesis.
Here, we describe the effect of type 1 cannabinoid receptor (CB1R) activation on self …

Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice

K Jin, L Xie, SH Kim, S Parmentier-Batteur, Y Sun… - Molecular …, 2004 - ASPET
Pharmacological studies suggest a role for CB1 cannabinoid receptors (CB1R) in regulating
neurogenesis in the adult brain. To investigate this possibility, we measured neurogenesis …

[HTML][HTML] Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis

SA Wolf, A Bick-Sander, K Fabel, P Leal-Galicia… - Cell Communication and …, 2010 - Springer
Background Adult neurogenesis is a particular example of brain plasticity that is partially
modulated by the endocannabinoid system. Whereas the impact of synthetic cannabinoids …

In vivo up‐regulation of brain‐derived neurotrophic factor in specific brain areas by chronic exposure to Δ9‐tetrahydrocannabinol

E Butovsky, A Juknat, I Goncharov… - Journal of …, 2005 - Wiley Online Library
Cannabinoids are widely abused drugs. Here we show that chronic administration of Δ9‐
tetrahydrocannabinol (Δ9‐THC), the active psychotropic agent in marijuana and hashish, at …

[HTML][HTML] CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3β/β-catenin signaling

S Trazzi, M Steger, VM Mitrugno, R Bartesaghi… - Journal of biological …, 2010 - ASBMB
The endocannabinoid system is involved in the regulation of many physiological effects in
the central and peripheral nervous system. Recent findings have demonstrated the …

The endocannabinoid system modulates a transient TNF pathway that induces neural stem cell proliferation

A Rubio-Araiz, Á Arévalo-Martín… - Molecular and Cellular …, 2008 - Elsevier
Evidence is emerging that the tumour necrosis factor (TNF-α) is a potent signal that induces
neural stem cell proliferation and migration. We show that NSC self-renewal is controlled by …

[HTML][HTML] The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis

T Aguado, E Romero, K Monory, J Palazuelos… - Journal of Biological …, 2007 - ASBMB
Endocannabinoids are lipid signaling mediators that exert an important neuromodulatory
role and confer neuroprotection in several types of brain injury. Excitotoxicity and stroke can …

Role for neuronal nitric-oxide synthase in cannabinoid-induced neurogenesis

SH Kim, SJ Won, XO Mao, C Ledent, K Jin… - … of Pharmacology and …, 2006 - ASPET
Cannabinoids, acting through the CB1 cannabinoid receptor (CB1R), protect the brain
against ischemia and related forms of injury. This may involve inhibiting the neurotoxicity of …