Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds

BR Lins, CC Anyaegbu, SC Hellewell, M Papini… - Journal of …, 2023 - Springer
Traumatic brain injury is common, and often results in debilitating consequences. Even mild
traumatic brain injury leaves approximately 20% of patients with symptoms that persist for …

The therapeutic potential of the cannabinoids in neuroprotection

RI Grundy - Expert opinion on investigational drugs, 2002 - Taylor & Francis
After thousands of years of interest the last few decades have seen a huge increase in our
knowledge of the cannabinoids and their mode of action. Their potential as medical …

Cannabinoids as neuroprotective agents in traumatic brain injury

A Biegon - Current pharmaceutical design, 2004 - ingentaconnect.com
The name “Cannabinoid” applies to a large and diverse family of compounds including plant
derived, synthetic and endogenously produced chemicals, some but not all of which are …

Endocannabinoids: a promising impact for traumatic brain injury

LD Schurman, AH Lichtman - Frontiers in pharmacology, 2017 - frontiersin.org
The endogenous cannabinoid (endocannabinoid) system regulates a diverse array of
physiological processes and unsurprisingly possesses considerable potential targets for the …

[HTML][HTML] Cannabinoids in neurodegenerative disorders and stroke/brain trauma: from preclinical models to clinical applications

J Fernández-Ruiz, MA Moro, J Martínez-Orgado - Neurotherapeutics, 2015 - Elsevier
Cannabinoids form a singular family of plant-derived compounds (phytocannabinoids),
endogenous signaling lipids (endocannabinoids), and synthetic derivatives with multiple …

[HTML][HTML] Cannabinoids and neuroinflammation: Therapeutic implications

BE Leonard, F Aricioglu - Journal of Affective Disorders Reports, 2023 - Elsevier
This review summarizes the pharmacological properties of tetrahydrocannabinol (THC) and
cannabidiol (CBD), cannabinoid components of several species of herbal cannabis. The …

Cannabinoids and brain injury: therapeutic implications

R Mechoulam, D Panikashvili, E Shohami - Trends in molecular medicine, 2002 - cell.com
Mounting in vitro and in vivo data suggest that the endocannabinoids anandamide and 2-
arachidonoyl glycerol, as well as some plant and synthetic cannabinoids, have …

Therapeutic potential of cannabinoids in CNS disease

JL Croxford - CNS drugs, 2003 - Springer
The major psychoactive constituent of Cannabis sativa, Δ 9-tetrahydrocannabinol (Δ 9-THC),
and endogenous cannabinoid ligands, such as anandamide, signal through G-protein …

The endocannabinoid system as a target for the treatment of neuronal damage

J Fernández-Ruiz, C García, O Sagredo… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: Cannabinoids have been proposed as clinically promising
neuroprotective molecules, based on their capability to normalize glutamate homeostasis …

Toward a translational approach to targeting the endocannabinoid system in posttraumatic stress disorder: a critical review of preclinical research

S Papini, GM Sullivan, DA Hien, E Shvil, Y Neria - Biological Psychology, 2015 - Elsevier
Despite the lack of clinical research, marijuana and synthetic cannabinoids have been
approved to treat posttraumatic stress disorder (PTSD) in several states in the United States …