Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis

J Gillard, M Suffiotti, P Brazda… - Nature …, 2024 - nature.com
Many countries continue to experience pertussis epidemics despite widespread vaccination.
Waning protection after booster vaccination has highlighted the need for a better …

Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination

E Van Schuppen, J Fröberg… - Nature …, 2022 - nature.com
Bordetella pertussis (Bp), the causative agent of pertussis, continues to circulate despite
widespread vaccination programs. An important question is whether and how (sub) clinical …

Bordetella pertussis Infection Exacerbates Influenza Virus Infection through Pertussis Toxin-Mediated Suppression of Innate Immunity

VI Ayala, JR Teijaro, DL Farber, SG Dorsey… - PLoS …, 2011 - journals.plos.org
Pertussis (whooping cough) is frequently complicated by concomitant infections with
respiratory viruses. Here we report the effect of Bordetella pertussis infection on subsequent …

Modification of innate immune responses to Bordetella pertussis in babies from pertussis vaccinated pregnancies

TF Rice, DA Diavatopoulos, Y Guo, B Donaldson… - …, 2021 - thelancet.com
Background Tetanus, diphtheria, acellular pertussis, inactivated polio (Tdap-IPV) vaccines
administered during pregnancy protect young infants from Bordetella pertussis (B. pertussis) …

Emerging Bordetella pertussis Strains Induce Enhanced Signaling of Human Pattern Recognition Receptors TLR2, NOD2 and Secretion of IL-10 by Dendritic Cells

ES Hovingh, M van Gent, HJ Hamstra, M Demkes… - PloS one, 2017 - journals.plos.org
Vaccines against pertussis have been available for more than 60 years. Nonetheless, this
highly contagious disease is reemerging even in countries with high vaccination coverage …

[HTML][HTML] A system-view of Bordetella pertussis booster vaccine responses in adults primed with whole-cell versus acellular vaccine in infancy

R da Silva Antunes, F Soldevila, M Pomaznoy… - JCI insight, 2021 - ncbi.nlm.nih.gov
The increased incidence of whooping cough worldwide suggests that current vaccination
against Bordetella pertussis infection has limitations in quality and duration of protection …

Lack of evidence supporting a role of IFN-β and TGF-β in differential polarization of Bordetella pertussis specific-T cell responses

R da Silva Antunes, LG Quiambao, F Soldevila… - Cytokine, 2021 - Elsevier
Bordetella Pertussis (BP) vaccine-induced immunity is waning worldwide despite excellent
vaccine coverage. Replacement of the whole-cell inactivated vaccine (wP) by an acellular …

Development and Validation of a Bordetella pertussis Whole‐Genome Screening Strategy

R da Silva Antunes, LG Quiambao… - Journal of …, 2020 - Wiley Online Library
The immune response elicited by the protective whole‐cell pertussis (wP) versus the less‐
protective acellular pertussis (aP) vaccine has been well characterized; however, important …

Antibody persistence 2 and 3 years after booster vaccination of adolescents with recombinant acellular pertussis monovalent aPgen or combined TdaPgen vaccines

P Pitisuttithum, J Dhitavat, C Sirivichayakul… - …, 2021 - thelancet.com
Background Recombinant pertussis vaccines inducing long-lasting immune responses
could help to control the rise in pertussis. We here report on persisting antibody responses 2 …

T cell reactivity to Bordetella pertussis is highly diverse regardless of childhood vaccination

R da Silva Antunes, E Garrigan, LG Quiambao… - Cell Host & Microbe, 2023 - cell.com
The incidence of whooping cough due to Bordetella pertussis (BP) infections has increased
recently. It is believed that the shift from whole-cell pertussis (wP) vaccines to acellular …