Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis

G Chen, S Zhou, Q Chen, M Liu, M Dong… - Frontiers in Molecular …, 2022 - frontiersin.org
Major depression (MD) is a severe mental illness that creates a heavy social burden, and
the potential molecular mechanisms remain largely unknown. Lots of research demonstrate …

Metabolomic abnormalities of purine and lipids implicated olfactory bulb dysfunction of CUMS depressive rats

Y He, Y Wang, Z Wu, T Lan, Y Tian, X Chen, Y Li… - Metabolic brain …, 2020 - Springer
Major depressive disorder (MDD) is a serious mood disorder and leads to a high suicide
rate as well as financial burden. The volume and function (the sensitivity and neurogenesis) …

Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS

Y Wu, Y Li, Y Jia, C Wei, H Xu, R Guo, Y Li, J Jia… - Molecular …, 2017 - pubs.rsc.org
Hypothalamic dysfunction is a key factor in depression; increasing evidence highlights
neuroinflammation abnormalities as well as imbalances in neurotransmitters and the …

2D-gel based proteomics unravels neurogenesis and energetic metabolism dysfunction of the olfactory bulb in CUMS rat model

K Cheng, J Li, D Yang, Y Yang, C Rao, S Zhang… - Behavioural Brain …, 2016 - Elsevier
Major depression is a devastating psychiatric disease worldwide currently. A reduced
olfactory sensitivity in MDD patients was well evidenced. We previously interrogated the …

Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice

K Xu, Y He, X Chen, Y Tian, K Cheng… - Journal of …, 2019 - Wiley Online Library
The proportion of major depressive disorder (MDD) patients around the world has increased
remarkably. Although many studies of MDD have been conducted based on classic …

Metabolomics identifies perturbations in amino acid metabolism in the prefrontal cortex of the learned helplessness rat model of depression

X Zhou, L Liu, Y Zhang, J Pu, L Yang, C Zhou, S Yuan… - Neuroscience, 2017 - Elsevier
Major depressive disorder is a serious psychiatric condition associated with high rates of
suicide and is a leading cause of health burden worldwide. However, the underlying …

Targeted metabolomic pathway analysis and validation revealed glutamatergic disorder in the prefrontal cortex among the chronic social defeat stress mice model of …

W Wang, H Guo, SX Zhang, J Li, K Cheng… - Journal of proteome …, 2016 - ACS Publications
Major depressive disorder (MDD) is a severe psychiatric disease that has critically affected
life quality for millions of people. Chronic stress is gradually recognized as a primary …

[HTML][HTML] Multi-omics analysis of the amygdala in a rat chronic unpredictable mild stress model of depression

X Li, X Zhou, T Teng, L Fan, X Liu, Y Xiang, Y Jiang… - Neuroscience, 2021 - Elsevier
Major depressive disorder is a serious and complex mental illness, and multiple brain
regions are involved in its pathogenesis. There is increasing evidence that the amygdala is …

[HTML][HTML] Proteomic and metabolomic characterization of amygdala in chronic social defeat stress rats

L Fan, L Yang, X Li, T Teng, Y Xiang, X Liu… - Behavioural Brain …, 2021 - Elsevier
Background Depression is a leading cause of disability worldwide. There is increasing
evidence showing that depression is associated with the pathophysiology in amygdala; …

Integrated metabolomics and proteomics analysis of hippocampus in a rat model of depression

Y Zhang, S Yuan, J Pu, L Yang, X Zhou, L Liu, X Jiang… - Neuroscience, 2018 - Elsevier
Major depressive disorder (MDD) is a prevalent and serious mental disorder with high rates
of suicide and disability. However, the underlying pathogenesis of MDD is complicated and …