[HTML][HTML] Bioactivities and mechanism of action of securinega alkaloids derivatives reported prior to 2022
W Hou, H Huang, XQ Wu, JX Lan - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Securinega alkaloids are indolizidine alkaloids extracted from the leaf and root of an Asian
plant, Securinega suffruticosa. Since its discovery in 1956 by Russian scientists, numerous …
plant, Securinega suffruticosa. Since its discovery in 1956 by Russian scientists, numerous …
Potential anticancer activities of securinine and its molecular targets
CJ Liu, XD Fan, JG Jiang, QX Chen, W Zhu - Phytomedicine, 2022 - Elsevier
Background Securinine is an alkaloid identified from the roots and leaves of the shrub
Flueggea suffruticosa (Pall.) Baill. The molecular structure of securinine consists of four …
Flueggea suffruticosa (Pall.) Baill. The molecular structure of securinine consists of four …
Securinega Alkaloids from the Twigs of Securinega suffruticosa and Their Biological Activities
Seven new Securinega alkaloids, securingines A–G (1–7), together with seven known
analogues (8–14), were isolated from the twigs of Securinega suffruticosa. Their chemical …
analogues (8–14), were isolated from the twigs of Securinega suffruticosa. Their chemical …
Chemical synthesis and biological activities of Securinega alkaloids
W Zhang, JY Li, P Lan, PH Sun, Y Wang… - Journal of Chinese …, 2011 - jcps.bjmu.edu.cn
The Securinega alkaloids are a group of compounds isolated from the plants of Securinega,
Phyllanthus and Flueggea genera belonging to the Euphorbiaceae family. Most of these …
Phyllanthus and Flueggea genera belonging to the Euphorbiaceae family. Most of these …
Securinega suffruticosa
D Raj, M Łuczkiewicz - Fitoterapia, 2008 - Elsevier
This review gives an account of the current knowledge on the chemical constituents,
biological activity and pharmacological properties of Securinega suffruticosa. A wide range …
biological activity and pharmacological properties of Securinega suffruticosa. A wide range …
Synthesis and antiproliferative and metabolic evaluations of novel securinine derivatives
M Perez, T Ayad, P Maillos, V Poughon… - ACS Medicinal …, 2016 - ACS Publications
New securinine analogues have been prepared by semisynthesis. Two series were
developed using either Suzuki or Sonogashira cross coupling reactions. The in vitro …
developed using either Suzuki or Sonogashira cross coupling reactions. The in vitro …
Total synthesis of the Securinega alkaloids
SM Weinreb - Natural Product Reports, 2009 - pubs.rsc.org
Covering: 1966 to the beginning of 2009The Securinega alkaloids are a small family of plant
metabolites with fascinating bridged tetracyclic structures and significant biological activity …
metabolites with fascinating bridged tetracyclic structures and significant biological activity …
The securinega alkaloids
E Chirkin, W Atkatlian, FH Porée - The alkaloids: chemistry and biology, 2015 - Elsevier
Securinega alkaloids represent a family of plant secondary metabolites known for 50 years.
Securinine (1), the most abundant and studied alkaloid of this series was isolated by …
Securinine (1), the most abundant and studied alkaloid of this series was isolated by …
Securinega Alkaloids: Complex Structures, Potent Bioactivities, and Efficient Total Syntheses
R Wehlauch, K Gademann - Asian Journal of Organic …, 2017 - Wiley Online Library
The Securinega alkaloids feature a compact tetracyclic structural framework and can be
divided into four subclasses characterized by either a bridged [2.2. 2]‐or a [3.2. 1]‐bicyclic …
divided into four subclasses characterized by either a bridged [2.2. 2]‐or a [3.2. 1]‐bicyclic …
Securinine from Phyllanthus glaucus Induces Cell Cycle Arrest and Apoptosis in Human Cervical Cancer HeLa Cells
J Stefanowicz-Hajduk, B Sparzak-Stefanowska… - PLoS …, 2016 - journals.plos.org
Background The Securinega-type alkaloids occur in plants belonging to Euphorbiaceae
family. One of the most widely distributed alkaloid of this group is securinine, which was …
family. One of the most widely distributed alkaloid of this group is securinine, which was …