Laboratory threat extinction paradigms and exposure-based therapy both involve repeated,
safe confrontation with stimuli previously experienced as threatening. This fundamental …

Laboratory models of extinction learning in animals and humans have the potential to
illuminate methods for improving clinical treatment of fear-based clinical disorders. However …

Background Experimental extinction serves as a model for psychiatric treatments based on
associative learning. However, the effects of extinction are often transient, as evidenced by …

A single session of exposure therapy can eliminate recalcitrant and disabling fear of
phobogenic objects or situations. We studied neural mechanisms of this remarkable …

Patients with anxiety disorders often experience a relapse in symptoms after exposure
therapy. Similarly, threat responses acquired during Pavlovian threat conditioning often …

Aberrant fear learning processes are assumed to be a key factor in the pathogenesis of
anxiety disorders. Thus, effective behavioral interventions to reduce dysfunctional fear …

Introduction It has long been posited that threat learning operates and forms under an
affective and a cognitive learning system that is supported by different brain circuits. A …

The measurement of Pavlovian forms of fear extinction offers a relatively simple behavioral
preparation that is nonetheless tractable, from a translational perspective, as an approach to …

Translational neuroscience for anxiety has had limited success despite great progress in
understanding the neurobiology of Pavlovian fear conditioning and extinction. This chapter …

Fear extinction is the decrease in conditioned fear responses that normally occurs when a
conditioned stimulus (CS) is repeatedly presented in the absence of the aversive …