Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potential
K Van De Ven, J Borst - Immunotherapy, 2015 - Taylor & Francis
In 2013, cancer immunotherapy was named 'breakthrough of the year'based on the outcome
of clinical trials with blocking antibodies to the T-cell co-inhibitory receptors CTLA-4 and PD …
of clinical trials with blocking antibodies to the T-cell co-inhibitory receptors CTLA-4 and PD …
Pro-survival signaling via CD27 costimulation drives effective CAR T-cell therapy
DG Song, DJ Powell - Oncoimmunology, 2012 - Taylor & Francis
The impact of CD27 costimulation on human T lymphocyte effector function and memory
formation has been limited to evaluations using in vitro cell culture systems and …
formation has been limited to evaluations using in vitro cell culture systems and …
CD27 Agonism Plus PD-1 Blockade Recapitulates CD4+ T-cell Help in Therapeutic Anticancer Vaccination
T Ahrends, N Bąbała, Y Xiao, H Yagita… - Cancer research, 2016 - AACR
While showing promise, vaccination strategies to treat cancer require further optimization.
Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral …
Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral …
The role of CD27 in anti-viral T-cell immunity
EJ Grant, S Nüssing, S Sant, EB Clemens… - Current opinion in …, 2017 - Elsevier
Highlights•CD27 is a co-stimulatory receptor expressed on T-cells, B-cells and NK-
cells.•CD27-CD70 co-stimulation enhances primary, memory and recall T-cell responses.• …
cells.•CD27-CD70 co-stimulation enhances primary, memory and recall T-cell responses.• …
[HTML][HTML] New emerging targets in cancer immunotherapy: CD27 (TNFRSF7)
AM Starzer, AS Berghoff - ESMO open, 2019 - Elsevier
ABSTRACT Cluster of differentiation 27 (CD27) is a member of the tumour necrosis factor
receptor superfamily and plays a key role in T-cell activation by providing a costimulatory …
receptor superfamily and plays a key role in T-cell activation by providing a costimulatory …
CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies
MF Al Sayed, CA Ruckstuhl… - Blood, The Journal …, 2017 - ashpublications.org
The interaction of the tumor necrosis factor receptor (TNFR) CD27 with its ligand CD70 is an
emerging target to treat cancer. CD27 signaling provides costimulatory signals to cytotoxic T …
emerging target to treat cancer. CD27 signaling provides costimulatory signals to cytotoxic T …
Agonist anti-human CD27 monoclonal antibody induces T cell activation and tumor immunity in human CD27–transgenic mice
LZ He, N Prostak, LJ Thomas, L Vitale… - The Journal of …, 2013 - journals.aai.org
The CD70/CD27 pathway plays a significant role in the control of immunity and tolerance,
and previous studies demonstrated that targeting murine CD27 (mCD27) with agonist mAbs …
and previous studies demonstrated that targeting murine CD27 (mCD27) with agonist mAbs …
[HTML][HTML] CD27-mediated regulatory T cell depletion and effector T cell costimulation both contribute to antitumor efficacy
A Wasiuk, J Testa, J Weidlick, C Sisson… - The Journal of …, 2017 - journals.aai.org
CD27, a member of the TNFR superfamily, is constitutively expressed in most T cells and
plays crucial roles in T cell effector functions. The costimulation and antitumor activity of …
plays crucial roles in T cell effector functions. The costimulation and antitumor activity of …
CD27 signaling increases the frequency of regulatory T cells and promotes tumor growth
Signaling of the TNF receptor superfamily member CD27 activates costimulatory pathways
to elicit T-and B-cell responses. CD27 signaling is regulated by the expression of its ligand …
to elicit T-and B-cell responses. CD27 signaling is regulated by the expression of its ligand …
Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence, and reduced PD-1 expression of tumor …
DJ Roberts, NA Franklin, LM Kingeter… - Journal of …, 2010 - journals.lww.com
The immune response to the tumor can be enhanced by targeting costimulatory molecules
on T cells. As the CD70-CD27 costimulatory axis plays an important role in the activation …
on T cells. As the CD70-CD27 costimulatory axis plays an important role in the activation …