The enormous diversity of bacteriophages and their bacterial hosts presents a significant
challenge to predict which phages infect a focal set of bacteria. Infection is largely …

Predicting how phages can selectively infect specific bacterial strains holds promise for
developing novel approaches to combat bacterial infections and better understanding …

Highlights•Phage-host interactions have mostly been studied one-by-one using few old
models.•Systematic approaches reveal new molecular mechanisms of phage-host …

Bacteriophages (phages) are critical players in the dynamics and function of microbial
communities and drive processes as diverse as global biogeochemical cycles and human …

Bacterial host factors regulate the infection cycle of bacteriophages. Except for some well-
studied host factors (eg, receptors or restriction-modification systems), the contribution of the …

As rising levels of antibiotic resistance limit treatment options against bacterial infections,
phage therapy offers a promising alternative. However, as bacteria and phage have co …

Metagenomics has changed the face of virus discovery by enabling the accurate
identification of viral genome sequences without requiring isolation of the viruses. As a …

Phages are increasingly considered promising alternatives to target drug-resistant bacterial
pathogens. However, their often-narrow host range can make it challenging to find matching …

Phages are increasingly considered as promising alternatives to target drug-resistant
bacterial pathogens. However, their often-narrow host range can make it challenging to find …

Bacteriophages can help the treatment of bacterial infections yet require in-silico models to
deal with the great genetic diversity between phages and bacteria. Despite the tolerable …