The timing of diverse cellular processes is based on the instant when the concentration of
regulatory proteins crosses a critical threshold level. Hence, noise mechanisms inherent to …

The timing of diverse cellular processes is based on the instant when the concentration of
regulatory proteins crosses a critical threshold level. Hence, noise mechanisms inherent to …

An important event in many cellular contexts is the crossing of a prescribed threshold by a
regulatory protein. The timing of such events is stochastic as a consequence of the innate …

Many cellular events occur when their corresponding regulatory proteins attain critical
thresholds. Can cells schedule such events with precision by controlling the dynamics of the …

Stochasticity in gene expression poses a critical challenge to the precise control of cellular
function. In this paper we examine how precisely can a stochastically expressed protein …

An important step in execution of several cellular processes is accumulation of a regulatory
protein up to a specific threshold level. Since production of a protein is inherently stochastic …

Burst-like synthesis of protein is a significant source of cell-to-cell variability in protein levels.
Negative feedback is a common example of a regulatory mechanism by which such …

Synthesis of individual molecules in the expression of genes often occurs in bursts of
multiple copies. Gene regulatory feedback can affect the frequency with which these bursts …

The stochastic nature of gene expression can lead to significant cell-to-cell variability in the
time at which a certain protein level is attained. This is reflected in the timing of cellular …

The timing of cellular events is inherently random because of the probabilistic nature of gene
expression. Yet cells manage to have precise timing of important events. Here, we study …